Thursday, February 9, 2023
Mitochondrial Health

Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats



My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.

Dr. Kennedy’s lab is working on different small molecules and natural products that could boost longevity. In today’s discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.

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DR. BRIAN KENNEDY LINKS:
Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/
Twitter: https://twitter.com/BKennedy_aging

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TIMESTAMPS:
00:00 Live Longer World
00:35 Brian Kennedy Intro
1:24 Differences in lifespan vs healthspan in his grandmothers
3:37 Network concept of the hallmarks of Aging
7:17 Open questions on hallmarks of aging; combining interventions
13:08 Comparing biomarkers of aging
16:11 Alpha-Ketoglutarate (AKG) and Longevity
23:55 Aging across different ethnicities
26:00 Socioeconomic & housing differences contributing to aging
29:40 Spermidine & Autophagy
31:59 Different longevity supplements may cancel each other out
35:18 AKG in extended release form
36:24 AKG & Red Blood Cells + Glutathione production
38:43 Mechanisms by which AKG works; AKG & Microbiome
40:07 Urolithin A, Mitochondria & Longevity
41:55 Longevity of Bats!
47:57 Yeast as model organisms for aging research
50:24 Advocating for Basic Science Research (Feynman: The Pleasure of Finding Things Out)
57:34 Support, share, and follow Live Longer World

DR. BRIAN KENNEDY RESEARCH DISCUSSED:
2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/
2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/
2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/
2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/
2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081

Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share!
Stay in good health – Aastha.

#briankennedy #akg #spermidine #urolithin #batlongevity #longevity #antiaging #biomarkers

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5 thoughts on “Dr. Brian Kennedy | Aging Networks & Biomarkers, AKG, Spermidine and Longevity of Bats
  1. This has become one of my favorite podcasts. Aashta is so knowledgeable and asks great questions. She gets more out of distinguished guests than most podcasts in this space. There are only a handful of top quality podcasts in health and longevity that get to this level of information, specificity and detail. It's impressive what she has created in such a short time!

  2. This was the best Brian Kennedy interview I have ever heard. Keep up the great work! You have a very soothing voice as well & know how to ask the right questions. Very good.

    I wonder what you think of George Church. His ideas I've realized are a little out there, but he is another that believes with some gene edits we can reverse aging. Yet I've never really heard a scientist give him an interview. Would be interested to know what you think of his work & if it is within the overall aging research community.

  3. Your youthful and young and pretty but all the people you interview have aged like every other human being so I think we have at least another 20 yrs to go to see results.

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