Sunday, February 5, 2023
Mitochondrial Health

TWiV 860: Evading a Toll on the road to RNA vaccines

TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.

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20 thoughts on “TWiV 860: Evading a Toll on the road to RNA vaccines
  1. Says all you need to know about humanity, at least anglo phone males, when you realise that Rogan is the most popular podcaster.
    Pity Musk can't stick him on a one way journey to Mars. And keep him company. They can podcast their exploits en route and in situ. Until they run out of air or starve or realise there is no one where on the planet to spend their fortunes. Musk can declare himself Emperor and Rogan can be his consort.
    That should work and surpassing all previous box office records is a given.

  2. I am just a lowly lawyer. But I think that the pandemic is far from over. My reasoning is this: Omicron is not descended from the Delta variant. My understanding that the leading theories are that it mutated in an immune compromised human, or another mammal host and jumped back into humans, or an isolated human population. Under any of these theories, the virus will be able to continue mutating into different fit variants and reinfect us. Am I wrong?

  3. Thanks for the great program. I think the Fermi paradox fails to deal with the numbers. There appear to be 10 to the 23rd power planets in the known universe and we are dealing with billions of years of planetary history. Even if there were only 1 in a trillion chances of a planet having conditions to support life as we know it that leaves 10 to the 14th chances. I will go with the odds. BTW Fermi didn't have the data on planetary incidence.

  4. Hi Vincent, I've found interesting the level of dissatisfaction at the public level stemming from Rogan's guests as of late. Spotify's stock is down 26% over the last month as artists and listeners leave. Rogan has had a whole series of like-minded people on and amplified their views. Immediately after Peter McCullough and Malone questioning vaccines, another guest questioned existence of climate change. In addition to Neil Young leaving other musicians have now followed suit including Nils Lofgren and Joni Mitchell, and the band Foo Fighters is rumored to be considering departing. Neil is the Godfather of grunge music and Foo Fighters is led by the former drummer for Nirvana.

  5. Biological systems seem generally to have evolved precise ways of recognising antigens and also 'things going wrong' with say Mitiochondria, which processes sugars etc for energy, so apoptosis might be induced in those that are either being modified or are not doing it rightly and the destruction of those cells means the "good" cells keep going. But this general or 'generical' process seems to happen wherever a danger is seen, or something is 'seen' to be such that it wont work. For this to evolve it seems as though it was not an accident. Not evolution. Almost controlled by some kind of super consciousness (or chemicals are 'thinking') …. But of course we are looking at an intricate processing that evolved over millions of years. But still, it seems insanely, eerily complex….

  6. After the Spotify fiasco Joe Rogen has said he will book guests that differ in opinion to his controversial ones. I think it’s time Vincent and Joe have a chat.

  7. Kale is ok to me if I mix it in with the whole wheat pasta and black beans. I use cayenne pepper and the taste is not noticeable. Also, I'll cook the kale in the microwave for 2 minutes. That softens it up and makes it go down easy. There are different types of kale and yes, they taste better, some of them. I accidentally got a big bag of 'rainbow' kale instead of organic, which is ok and it tastes good.

    The main reason I eat kale is nutrients. I am on a whole food-plant based diet and track nutrients of standard meals because plant-only eaters can have a hard time reaching reasonable amounts of certain nutrients such as calcium. Kale does pretty good to help with that. If one is eating healthier dark leafy greens, then avoiding too much spinach can be beneficial because there is an association with kidney stones to high spinach intake.

    Kale is most important to me for the heart-healthy benefit of containing nutrients that produce nitric oxide, which is the Teflon of the endothelium, the lining of the blood vessels. Most people, including myself, have atherosclerosis to some extent. This aids in repair more than any other food due to the nitric oxide. It is recommended by Caldwell Esselstyn, Cleveland Clinic cardiologist who assisted in treatment of Bill Clinton. I don't have problems like he did but I am preventing it. πŸ™‚

  8. This IS "rocket science". Appreciate being led through the steps even if I do not have the background to understand all the details. And that is just fine. I do not know how to do the mathematics in astrophysics or the Standard Model but I have listened to people explaining the steps that lead to our current understanding of these fields and get the same from this. Well done, thank you.

  9. I've watched for a while. Science changes, I get that. I've heard you all state 1)we don't need multiple jabs, but also 2) that it's here for good. Does this mean we will get annual shots or not??

  10. I really enjoy TWiV and learn something interesting in each episode. However, I must admit I noticed on several occasions that the misunderstanding of NHST (null hypothesis statistical testing) and so called 'statistical significance' is as prevalent in biological sciences as it is in social ones.
    At about 1:01:00, Cathy is exhibiting a textbook example of that misunderstanding. It's too bad as the show is really rich.
    Unfortunately the expertise in a subject is only as relevant as one's knowledge of statistics. There is no way around it. Unless the subject is purely qualitative, that is.

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