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Berberine is a plant derived chemical that recent research has shown to be effective in prolonging longevity. First, it has been shown to increase the AMPK activation and mitigate AMPK inhibitor. There’s growing evidence that increasing AMPK activity can prevent pathological aging and can even reverse aging. AMPK is a regulator of cellular and organismal metabolism that plays a critical role in regulating physiological processes and metabolism. Its activation promotes ATP production and inhibits anabolic pathways. ATP is the energy currency of the cell that drives many cellular processes, for example, muscle contraction and nerve impulse transmission. According to a study, abundant ATP levels must be maintained in order to survive during extended longevity. Individuals who have major chronic diseases such as inflammation and diabetic chronic kidney disease have dysregulated AMPK and impaired ATP production. Activated AMPK promotes physiological and metabolic processes that protect the body tissues from aging processes. For example, AMPK destroys defective mitochondria, which is one of the major characteristics of degenerative diseases and aging, then stimulates the synthesis of new healthy mitochondria in order to maintain cellular homeostasis and health. Moreover, AMPK activation induces autophagy in the Drosophila’s nervous system, in which pathogens, damaged and unwanted molecules and organelles are destroyed, which induces regeneration of newer and healthier cells. This process can help regulate the homeostasis in the central nervous system.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.