Sunday, February 5, 2023
Mitochondrial Health

Low Dose Naltrexone (LDN) – Mechanism of Action

Low Dose Naltrexone (LDN) – Mechanism of Action

LDN is used for chronic diseases, multiple sclerosis, autoimmune thyroid disease, and various cancers. Let’s review its mechanism of action.

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Wednesday, Feb. 2 2022

Naltrexone | Naltrexone – Bupropion Combination – Mechanism of Action

IL-6 in Inflammation, Immunity, and Disease – PMC

Ventral tegmental area – Wikipedia

Mesolimbic pathway – Wikipedia

Striatum – Wikipedia

Frontiers | Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors | Immunology


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46 thoughts on “Low Dose Naltrexone (LDN) – Mechanism of Action
  1. Check out Walter M Chestnut findings on Twitter re cancer since operation wrap speed. Complex studies but worth a look if you have basic understanding of epidemiology.

  2. Dr Been .. Can you offer hope for overcoming methadone treatment/addiction … or perhaps some mitigation's while reducing dosage? i am not medically trained, so you seem to me as a walking textbook. also .. In my bout with the virus I was ill prepared .. while I have been taking my vitamins, and I am a very healthy outside laborer, I did not have the early anti viral treatment at hand when needed … I have learned that knowledge without appropriate action doesnt work to well … but I'm still here, thank God. God bless you in your efforts.

  3. WOW… Thank You!!!
    I have taken LDN for a few years now, when it began to be tried for Fibromyalgia… I also happen to have Hashimotos and other conditions.
    Te fact that the benefits can also come from immune system modulation.
    This is mind blowing.
    I am wondering if I should try to go up to 3 doses of the low dose per day????
    I would be happy to be a scientific trial guina pig on that.

  4. Hi Dr. Been, these lectures are such a gift. It's like being back in college without the looming, staggering, debt. I just bought you 3 coffees, wish I could do more. Don't lose faith in the power of honestly and transparently disseminating these studies for us. Keep on keeping on!

  5. My daughter took LDN for her ulcerative colitis some time ago. We were hopeful, but after a few days she developed a rash on her face. I researched, and was concerned that it was due to her liver detox, so we discontinued. Your lectures are teaching me a lot about her autoimmune disease and hoping I will learn enough to heal her. She is not vaccinated because she is in early 20s and felt she would risk her recent remission. Any advice on what to do if she gets Omicron. She has been around everyone and never gotten Covid. Do you think that has to do with her aggressive immune system, and when she does finally get it so you think she will have more chance of cytokine storm?Thanks you for all you do!

  6. Thank you so much Dr. Bean! I was really hoping that you would eventually get in to helping those of us with auto immunity.

    I have had Eldean in my house for months, but my Doctor Who prescribed it was nervous about using it, and so I became the same. I had talked him into using it now I will give it a try. ❤️

    It is really helpful to hear your educational presentation, and also to read the comments from those who have already tried it, both with Long covid and With auto immune issues. This forum is so wonderful!

  7. Thank you for your thorough, complex, yet accessible explanation. When I started LDN for ME/CFS, it was like a low ceiling that was making me crouch all the time had been lifted. All the normal things I had been doing to optimize good health suddenly became effective, too. (No sugar, milk, wheat, industrial store-bought eggs, etc., good supplements, outdoor sunshine and fresh air, very gentle, limited exercise/ movement, etc.)

  8. Thank you doctor. The part of this lecture that talked about collagen overproduction really struck me. I ended up with ANA tests showing for Scleroderma (SCL70) as a post covid result. I had everything else as well – sore joints, sore muscles, fatigue, plus more. After going through 10 MD specialists an ND put me on LDN. I dealt with these long haul symptoms for 10 months before LDN was introduced. I am now a full year into my LDN regiment and my symptoms are so well controlled I sometimes think they're gone. Also, after a year and a half of high ANA test results the last test came back negative. Not sure if it's all thanks to LDN or LDN plus the other anti-inflammatories my ND has me on but either way I have improved.

  9. DR BEEN: what about low dose doxycycline/oracea? seems like it works the same way to decrease inflammation, would it help with long covid symptoms? My son is suffering from Vax injury from pfizer, has the typical long covid symptoms 9 months out from 2nd dose.

  10. Think about it. For example, when I was younger I found that I could eat 300-400 calories of lean meat, and not get hungry or think about food for 10 hours. Any fiber at the same calories bloated me and passed out of the stomach in 90 minutes, leaving me starving. My job was lifting 40 lb things all day and going up and down ladders.

    Thus, I learned that all plants were a waste of calories, because my goal, in the year 2000, was calorie counting to loose weight.

    So, a 1100 calorie day, cutting out foods with inadequate hunger satiation was a whole lot easier on a low carb diet. It is was also a lot easier to maintain the 60 lb in 6 month of weight loss.

    Hunger per calorie is the number one thing.

    For example, if you came out with a food that 100 calories stopped the hunger and gave all the energy you need for the next 24 hours, you would not compare a 1500 calorie diet of that food with 1500 calories of a balanced diet. That would be stupid. Just as stupid as this study.

    The idea of low carb is to keep the body burning fat, and not switch over to glucose burning beyond the glucose that the liver makes. It is also about keeping insulin low by zero carbs, or as low as possible. It is best to burn your own fat, which is why all diets can dip into a ketotic state. It is a matter of how much you are knocking yourself out of ketosis by eating sugar in any form, including carbs..

    One diabetic doctor pointed out that he can make the thinnest person fat, by prescribing insulin.

  11. Thank you Dr Been for this discussion. I’ve been on LDN for over 3 1/2 years, as prescribed by my alternative doctor, for fibromyalgia. It has to be made by a compounding pharmacy because LDN used for fibro is really used as an off-label drug, since it’s not actually FDA approved for autoimmune diseases and fibromyalgia. I have to pay a LOT for a 1-month supply x’s 12 (p/year). Maybe that has changed in the last few years…I will have to check with my doctor to see if I am able to get it through a regular pharmacy now. 🥰

  12. i love this as i have Multiple Sclerosis and had it for 30 years and theres a lot of people i know take low dose naltraxone for there MS with very good results,i keep thinking of trying it but i am a bit scared to take drugs.Its a case of it works very well for some and not at all for others.There is one lady i know of that was very ill and very disabled with her MS and when she started taking it she could live a normal life and her MS symptoms went away.

  13. Dr. I have Lupus and arthritis so I have chronic pain. LDN has been recommended for me but I take morphine ER 15 mg and they say I can’t take it. I’m afraid to go off morphine due to pain. Any recommendations?

  14. Asked my GP today (England, UK) to prescribe me this medication and he just pulled a weird face at me and said no you won’t get that from us. I tried to explain the mechanism behind it and he wasn’t interested at all. It’s actually becoming insidious how they would rather us suffer at home and in silence creating permanent chronic damage than to help give us medicines which will obviously get rid of this.
    If anyone is in the UK and knows of any doctors I can go to who are on board with this protocol or FLCCC PLEASE let me know
    (Already tried Dr Tina Peers she is full to capacity not seeing any more patients)

  15. Thank you so much Dr been. Am going to approach doctors (again) armed with this information and see if I can finally get started on something to help break the cycle, having had LC since March 20 with many obvious symptoms pertaining to this pathway but no pro-active help. Just told nothing can be done & ivm not available yet nothing else suggested. I suggested it was mcas a year ago but wasn't heard. Just gave up. Meanwhile a year more of potential damage has been done.
    Bless you for all you do and have done, and I'm so pleased you and your family have recovered 🙏❤️

  16. I've been a long hauler for 6 months. I did Dr. Patterson's cytokine panel and I have 7 markers high except for IL-6. Would LDN still be beneficial to take since my IL-6 is within normal range? And does it only target IL-6?

    Also they mentioned my T cells are washed out. Would this help with those as well? Thanks

  17. Fascinating! I actually use LDN to treat CRPS and its the only thing that helps. Drs very reluctant to orescribe it, thankfully my GP is amazing and looked at the studies I had and let me try it

  18. Naltrexone (Oral Route) Side Effects – Mayo Clinic

    Drug information provided by: IBM Micromedex

    Check with your doctor immediately if any of the following side effects occur:

    Less common

    Skin rash


    Abdominal or stomach pain (severe)

    blurred vision, aching, burning, or swollen eyes

    chest pain


    discomfort while urinating or frequent urination


    hallucinations or seeing, hearing, or feeling things that are not there


    mental depression or other mood or mental changes

    ringing or buzzing in the ears

    shortness of breath

    swelling of the face, feet, or lower legs

    weight gain

    More common

    Abdominal or stomach cramping or pain (mild or moderate)

    anxiety, nervousness, restlessness or trouble sleeping


    joint or muscle pain

    nausea or vomiting

    unusual tiredness

    Less common



    cough, hoarseness, runny or stuffy nose, sinus problems, sneezing, or sore throat



    fast or pounding heartbeat

    increased thirst


    loss of appetite

    sexual problems in males

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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