Low Dose Naltrexone (LDN) – Mechanism of Action
LDN is used for chronic diseases, multiple sclerosis, autoimmune thyroid disease, and various cancers. Let’s review its mechanism of action.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Feb. 2 2022
Naltrexone | Naltrexone – Bupropion Combination – Mechanism of Action
https://psychscenehub.com/psychinsights/naltrexone-naltrexone-bupropion-combination-mechanism-of-action-psychopharmacology-and-clinical-application-2/
IL-6 in Inflammation, Immunity, and Disease – PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4176007/
Ventral tegmental area – Wikipedia
https://en.wikipedia.org/wiki/Ventral_tegmental_area
Mesolimbic pathway – Wikipedia
https://en.wikipedia.org/wiki/Mesolimbic_pathway
Striatum – Wikipedia
https://en.wikipedia.org/wiki/Striatum#Structure
Frontiers | Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors | Immunology
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00809/full
source
Check out Walter M Chestnut findings on Twitter re cancer since operation wrap speed. Complex studies but worth a look if you have basic understanding of epidemiology.
Dr Been .. Can you offer hope for overcoming methadone treatment/addiction … or perhaps some mitigation's while reducing dosage? i am not medically trained, so you seem to me as a walking textbook. also .. In my bout with the virus I was ill prepared .. while I have been taking my vitamins, and I am a very healthy outside laborer, I did not have the early anti viral treatment at hand when needed … I have learned that knowledge without appropriate action doesnt work to well … but I'm still here, thank God. God bless you in your efforts.
What is the difference between naltrexone and noloxen? Does it offer the same benefits?
Thankyou.
This is a great, innovative video.
Hello Professor
sir, I’ve recently been diagnosed with osteoporosis As well , forgot to mention.
Would this be something that could help Sarcodiosis? I'd like to talk to my Doctor about it.
WOW… Thank You!!!
I have taken LDN for a few years now, when it began to be tried for Fibromyalgia… I also happen to have Hashimotos and other conditions.
THIS IS EYE OPENING!
Te fact that the benefits can also come from immune system modulation.
This is mind blowing.
I am wondering if I should try to go up to 3 doses of the low dose per day????
I would be happy to be a scientific trial guina pig on that.
“Diseases of the soul are more dangerous and more numerous than those of the body. “Cicero
QUESTION…. Would dose 4.5 twice a day be too much?
THANKS!
Hi Dr. Been, these lectures are such a gift. It's like being back in college without the looming, staggering, debt. I just bought you 3 coffees, wish I could do more. Don't lose faith in the power of honestly and transparently disseminating these studies for us. Keep on keeping on!
When I used to jog, the endorphins would make even this depressed person feel great.
Naltrexone is only to be used on opiate overdoses just as Loofymectin is only used on parasitic worm infections. /s
My daughter took LDN for her ulcerative colitis some time ago. We were hopeful, but after a few days she developed a rash on her face. I researched, and was concerned that it was due to her liver detox, so we discontinued. Your lectures are teaching me a lot about her autoimmune disease and hoping I will learn enough to heal her. She is not vaccinated because she is in early 20s and felt she would risk her recent remission. Any advice on what to do if she gets Omicron. She has been around everyone and never gotten Covid. Do you think that has to do with her aggressive immune system, and when she does finally get it so you think she will have more chance of cytokine storm?Thanks you for all you do!
Any thought on the reasons why exactly high dose naltrexone does not produce immunomodulatory effect, but low dose does?
Thank you so much Dr. Bean! I was really hoping that you would eventually get in to helping those of us with auto immunity.
I have had Eldean in my house for months, but my Doctor Who prescribed it was nervous about using it, and so I became the same. I had talked him into using it now I will give it a try. ❤️
It is really helpful to hear your educational presentation, and also to read the comments from those who have already tried it, both with Long covid and With auto immune issues. This forum is so wonderful!
Thank you for your thorough, complex, yet accessible explanation. When I started LDN for ME/CFS, it was like a low ceiling that was making me crouch all the time had been lifted. All the normal things I had been doing to optimize good health suddenly became effective, too. (No sugar, milk, wheat, industrial store-bought eggs, etc., good supplements, outdoor sunshine and fresh air, very gentle, limited exercise/ movement, etc.)
What a fantastic discussion with so many implications for many with autoimmune problems etc.
Thank you doctor. The part of this lecture that talked about collagen overproduction really struck me. I ended up with ANA tests showing for Scleroderma (SCL70) as a post covid result. I had everything else as well – sore joints, sore muscles, fatigue, plus more. After going through 10 MD specialists an ND put me on LDN. I dealt with these long haul symptoms for 10 months before LDN was introduced. I am now a full year into my LDN regiment and my symptoms are so well controlled I sometimes think they're gone. Also, after a year and a half of high ANA test results the last test came back negative. Not sure if it's all thanks to LDN or LDN plus the other anti-inflammatories my ND has me on but either way I have improved.
Yes outstanding
I love your drawings and diagrams, they tickle my funny bone. I really enjoy these informative videos.
You are great! You are expressive, knowledgeable and use your words wisely. I am happy to subscribe to you channel.
DR BEEN: what about low dose doxycycline/oracea? seems like it works the same way to decrease inflammation, would it help with long covid symptoms? My son is suffering from Vax injury from pfizer, has the typical long covid symptoms 9 months out from 2nd dose.
Great presentation Dr. What would be interesting would be the effects of microdosing LDN, say 0.5 mg as a protective mechanism for healthy individuals?
Think about it. For example, when I was younger I found that I could eat 300-400 calories of lean meat, and not get hungry or think about food for 10 hours. Any fiber at the same calories bloated me and passed out of the stomach in 90 minutes, leaving me starving. My job was lifting 40 lb things all day and going up and down ladders.
Thus, I learned that all plants were a waste of calories, because my goal, in the year 2000, was calorie counting to loose weight.
So, a 1100 calorie day, cutting out foods with inadequate hunger satiation was a whole lot easier on a low carb diet. It is was also a lot easier to maintain the 60 lb in 6 month of weight loss.
Hunger per calorie is the number one thing.
For example, if you came out with a food that 100 calories stopped the hunger and gave all the energy you need for the next 24 hours, you would not compare a 1500 calorie diet of that food with 1500 calories of a balanced diet. That would be stupid. Just as stupid as this study.
The idea of low carb is to keep the body burning fat, and not switch over to glucose burning beyond the glucose that the liver makes. It is also about keeping insulin low by zero carbs, or as low as possible. It is best to burn your own fat, which is why all diets can dip into a ketotic state. It is a matter of how much you are knocking yourself out of ketosis by eating sugar in any form, including carbs..
One diabetic doctor pointed out that he can make the thinnest person fat, by prescribing insulin.
Thank you Dr Been for this discussion. I’ve been on LDN for over 3 1/2 years, as prescribed by my alternative doctor, for fibromyalgia. It has to be made by a compounding pharmacy because LDN used for fibro is really used as an off-label drug, since it’s not actually FDA approved for autoimmune diseases and fibromyalgia. I have to pay a LOT for a 1-month supply x’s 12 (p/year). Maybe that has changed in the last few years…I will have to check with my doctor to see if I am able to get it through a regular pharmacy now. 🥰
i love this as i have Multiple Sclerosis and had it for 30 years and theres a lot of people i know take low dose naltraxone for there MS with very good results,i keep thinking of trying it but i am a bit scared to take drugs.Its a case of it works very well for some and not at all for others.There is one lady i know of that was very ill and very disabled with her MS and when she started taking it she could live a normal life and her MS symptoms went away.
So well explained, once again! 🙏🏻
Dr. I have Lupus and arthritis so I have chronic pain. LDN has been recommended for me but I take morphine ER 15 mg and they say I can’t take it. I’m afraid to go off morphine due to pain. Any recommendations?
Let us bow down and beg the FDA and CDC for our lives and our children's' lives
this drug will NIOT restore the immune system that the vaccine has destroyed….will it….be truthful here
Asked my GP today (England, UK) to prescribe me this medication and he just pulled a weird face at me and said no you won’t get that from us. I tried to explain the mechanism behind it and he wasn’t interested at all. It’s actually becoming insidious how they would rather us suffer at home and in silence creating permanent chronic damage than to help give us medicines which will obviously get rid of this.
If anyone is in the UK and knows of any doctors I can go to who are on board with this protocol or FLCCC PLEASE let me know
(Already tried Dr Tina Peers she is full to capacity not seeing any more patients)
Thank you so much Dr been. Am going to approach doctors (again) armed with this information and see if I can finally get started on something to help break the cycle, having had LC since March 20 with many obvious symptoms pertaining to this pathway but no pro-active help. Just told nothing can be done & ivm not available yet nothing else suggested. I suggested it was mcas a year ago but wasn't heard. Just gave up. Meanwhile a year more of potential damage has been done.
Bless you for all you do and have done, and I'm so pleased you and your family have recovered 🙏❤️
Other than HIV, have you ever heard of a virus with more talk concerning the IMMUNE system? I can't think of a SINGLE one… Covid is reminding me a lot of AIDS
When is it too late to try LDN for chronic disease? How long (roughly) would one use it to pause the immune system creating IL6?
I've been a long hauler for 6 months. I did Dr. Patterson's cytokine panel and I have 7 markers high except for IL-6. Would LDN still be beneficial to take since my IL-6 is within normal range? And does it only target IL-6?
Also they mentioned my T cells are washed out. Would this help with those as well? Thanks
Where can I find a prescriber to obtain this? No one locally will even consider trying it.
is there a test for overproduction of IL 6? does it cross or need to cross blood brain barrier as well?
Fascinating! I actually use LDN to treat CRPS and its the only thing that helps. Drs very reluctant to orescribe it, thankfully my GP is amazing and looked at the studies I had and let me try it
Thank you for the video. I had just heard of this while searching for treatments for ME/CFS.
Naltrexone (Oral Route) Side Effects – Mayo Clinic
Drug information provided by: IBM Micromedex
Check with your doctor immediately if any of the following side effects occur:
Less common
Skin rash
Rare
Abdominal or stomach pain (severe)
blurred vision, aching, burning, or swollen eyes
chest pain
confusion
discomfort while urinating or frequent urination
fever
hallucinations or seeing, hearing, or feeling things that are not there
itching
mental depression or other mood or mental changes
ringing or buzzing in the ears
shortness of breath
swelling of the face, feet, or lower legs
weight gain
More common
Abdominal or stomach cramping or pain (mild or moderate)
anxiety, nervousness, restlessness or trouble sleeping
headache
joint or muscle pain
nausea or vomiting
unusual tiredness
Less common
Chills
constipation
cough, hoarseness, runny or stuffy nose, sinus problems, sneezing, or sore throat
diarrhea
dizziness
fast or pounding heartbeat
increased thirst
irritability
loss of appetite
sexual problems in males
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
I’m 28 years of age (male), I have ASD, ME/CFS, chronic pain and just been diagnosed with Rheumatoid Arthritis. LDN and high dose CBD is my first go-to.
What is the dose and rhythm of administration?
Is its effectiveness for other diseases like Hashimoto proved in clinical trials?
Some used Naltrexone for cancers …seems like a good medicine to help people with chronic disease.
Are there blood tests that can identify the different toxic issues going on? Identify causes of chronic disease by bloodwork and symptom evidence.