Saturday, May 28, 2022
Mitochondrial Health

Marijuana may be the key to the prevention of neurodegenerative diseases such as Parkinson's diseas



it could also work in a wide variety of cells with ample therapeutic potential.” The study has implications for a range of neurodegenerative diseases such as Parkinson’s – which is also linked to glutathione loss. Prof Maher said according to new research. Cannabis is also said to contain a chemical that protects brain cells against ageing. The compound CBN is non-psychoactive “We’ve found cannabinol protects neurons from oxidative stress and cell death – two of the major contributors to Alzheimer’s. “This discovery could one day lead to the development of new therapeutics for treating this disease and other neurodegenerative disorders – like Parkinson’s disease.” Studies on medical cannabis have focused on the active substances THC and CBD a change that is seen in the brains of people with Alzheimer’s. When the cells were injected with CBN they maintained their healthy shape – and kept them functioning well. Prof Maher said “Mitochondrial dysfunction is implicated in changes in various tissues – not just in the brain and ageing. “So the fact this compound is able to maintain mitochondrial function suggests it could have more benefits beyond the context of Alzheimer’s disease.” She called for further research into CBN and other lesser-studied cannabinoids in the marijuana plant. Prof Maher and colleagues are now seeing if they can reproduce the results in a pre-clinical mouse model. Read More Cannabis compounds can protect against Covid infections “We were able to directly show maintenance of mitochondrial function was specifically required for the protective effects of the compound.” The study also showed CBN did not activate cannabinoid receptors – meaning that medications containing it would work without making the person taking it “high”. Video Loading Video Unavailable Click to play Tap to play The video will auto-play soon8Cancel Play now First author Dr Zhibin Liang said meaning it doesn’t get people high. Senior author Professor Pamela Maher said but now they say they have worked out the mechanism. Lab experiments showed CBN stops a type of cell death called oxitosis which is triggered by the loss of an antioxidant called glutathione. During the study Marijuana may be the key to the prevention of neurodegenerative diseases such as Parkinson’s disease. Cannabis could hold the key to preventing neurodegenerative diseases like Parkinson’s and Alzheimer’s which is the power stations of cells. Sign up to our newsletter to get the day’s biggest news straight to your inbox The Mirror’s newsletter brings you the latest news

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