Sunday, February 5, 2023
Mitochondrial Health

What is the Effect of Calorie Restriction on Lifespan and Healthspan? Dr. Eric Verdin Explains.

In his presentation entitled “NAD Metabolism and Aging: Therapeutic Opportunities”, Dr. Eric Verdin, president and CEO of the Buck Institute for Research on Aging, attempts to open the ‘black box’ of caloric restriction’s impact on healthspan and lifespan. To that end, he examines metabolites that fluctuate as a function of caloric input in order to understand how the variation of such metabolites is able to affect the activity of genetic regulators. In particular, Dr. Verdin focuses specifically on the interaction between NAD+ and Sirtuin.



Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, is also a professor of medicine at University of California, San Francisco, and his name appears on over two hundred research papers and fifteen patents. He studies the effects of small molecules, diet, and metabolism on histone deacetylases and sirtuins, which affect aging. He is among the top 1 percent of cited scientists and has received a Glenn Award for Research in Biological Mechanisms of Aging and a senior scholarship from the Ellison Medical Foundation. Dr. Verdin has extensive experience working with biotech companies. He founded Acylin, which has since been purchased by Abbvie, and he has served on the scientific advisory boards of Elixir, Sirtris, and the well-known Google holding Calico. Dr. Verdin has also consulted for multiple biotech companies, including Novartis, GSK, J&J, Altana, Roche, and Pfizer. His scientific memberships include the American Association for the Advancement of Science, the American Society for Clinical Investigation, and the Association of American Physicians, and he is on the advisory council of the National Institute on Drug Abuse at the National Institutes of Health.

The Buck Institute for Research on Aging pioneers research on aging, and is a global leader in the field. They opened its doors in 1999, becoming the world’s only research institution singularly focused on the biology of aging, yielding insights into age-related diseases before they start. They hire scientists from a variety of disciplines to attack the problem from all sides because the answer to aging will not come from a single field.

The annual Ending Age-Related Diseases (EARD) conference by brings together longevity thought leaders together to exchange research reports, inspire and get inspired with new ideas, find collaborators, supporters, and mentors.

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