Study, Notes, & Amendments: https://www.physionic.org/examine/%5B27%5D-protection-from-palmitate-induced-mitochondrial-dna-damage-prevents-from-mitochondrial-oxidative-stress%2C-mitochondrial-dysfunction%2C-apoptosis%2C-and-impaired-insulin-signaling-in-rat-l6-skeletal-muscle-cells
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0:00 – Introduction
1:50 – Saturated Fat on Mitochondrial DNA Damage
3:19 – Saturated Fat on Cell Energy
4:11 – Saturated Fat on Oxidative Stress
4:51 – Saturated Fat on Cell Survival
5:34 – One Mechanism
6:51 – Conclusions
Created with Biorender.
#saturatedfat #mitochondriahealth #musclehealth
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Nic, your editing is getting real good!
Shalom Nick, wishing you a fulfilling day of exploration and explanation. Stay awesome, thank you
Thanks for putting out this type of content. Have a great day, brother.
Why would we make our own saturated fat if it is bad for us? De novo lipogenesis makes several kind of saturated fat, including palmitate.
🧐 other types of fats fare worse then!
I'M MOST CURIOUS OF STEARIC ACID'S ROLL IN THIS PLAY …. HOPING FOR HAPPY ENDING
So don’t eat carbohydrates because you’ll store any excess as ~47% SFA to be burned later.
Great video, thanks for explaining the study so clearly.
Would you’d agree that this study shows exactly why it’s important for us to keep our fat inside adipocytes and avoid the insulin resistance causing cause them to leech out fat that causes havoc in other tissues?
Given that palmitate is produced from excess carbs and those same carbs are implicated insulin resistance, would you concur that this study supports the argument that the standard American diet is detrimental to health and that a low carb diet is the way to go?
Hi, like your videos. There is a guy Bart kay slamming you huge in a live stream.right now.
https://youtu.be/s9joJQox3fU
Getting destroyed never looked or sounded so good
You need to see what a real scientist has to say about this on Bart Kay's channel!
Nic debate Barr Kay, this isnt going to blow over, because he's pointing out that you have no idea what you're talking about… if you think your smart enough to educate online, then you should be ready to back up what you preach…
https://youtu.be/s9joJQox3fU Debunk is here. Seriously Nicholas, STOP son, you're making a fool of yourself.
Does a saturated fat diet directly imply negatively the mitochondria?
Any conclusion based ONLY in Macro nutrient factors and done in vitro with out measuring quality and nutrition value of whole of foods in humans means nothing to me… UV light oxides us as well… the same that oxygen at every moment … or mTOR pathways… ROS arguments are all empty for me.
good videos thanks
How does this concept of mitochondrial cell disfunction and cell death square with body builders eating significant quatities of red meat and its saturated fat? Body builders have been eating that way for decades and decades. How does this fit within a context of an athlete that burns fat for long endurance events in order to spare muscle glycogen? Prior to becoming "fat adapted" my muscles a didn't know what to do with fat. As a cyclist training upwards of 20 hrs a week I could never burn my belly fat or love handle. I was strong, but I ate a boat load of carbs. Since I've a drastically reduced carb intake 3.5 yrs ago, I'm a stronger, leaner athlete with seemingly "endless" ability to run… limited only by connecting tissue adaptations, rather than muscle fatigue. What do you think? Did the study use muscle tissue from a fat adapted, insulin sensitive person, or maybe from an insulin resistant person, or maybe a carb only fueling athlete. How do I fit into this paradigm? I'm certainly not wasting away. I'm very curious and wondering. I eat quite a bit of saturated fat, and honestly feel great, but I dunno. Thanks for your thoughts.
I will add some insults; ‘egomaniac ad board’
Make a video on stem cell therapy which to take allogenic or autologous
This is your best oration yet, extremely clear and informative. Keep up the awesome work.
Please cover both of the suggested follow up topics at the end of the video, that would be extremely interesting.
so what this rodent study proves (if anything) is that rats are herbivorous, and thus do not share the same genetic adaptations humans do for safely consuming saturated fat.
conclusion: rodent models are not appropriate for determining human nutrition, and any research attempting to make such parallels should be deemed invalid and irrelevant. good. not sure why your conclusion was different, perhaps you used the wrong slide? I'll assume so.
What is this DNA enzyme? Is it produced in the body and, if so, is the amount produced variable by genetics, age, or other factors?