Wednesday, February 8, 2023
Mitochondrial Health

Saturated Fat and its Role in Muscle Mitochondria Dysfunction [Study 27]



Study, Notes, & Amendments: https://www.physionic.org/examine/%5B27%5D-protection-from-palmitate-induced-mitochondrial-dna-damage-prevents-from-mitochondrial-oxidative-stress%2C-mitochondrial-dysfunction%2C-apoptosis%2C-and-impaired-insulin-signaling-in-rat-l6-skeletal-muscle-cells

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0:00 – Introduction
1:50 – Saturated Fat on Mitochondrial DNA Damage
3:19 – Saturated Fat on Cell Energy
4:11 – Saturated Fat on Oxidative Stress
4:51 – Saturated Fat on Cell Survival
5:34 – One Mechanism
6:51 – Conclusions

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#saturatedfat #mitochondriahealth #musclehealth

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24 thoughts on “Saturated Fat and its Role in Muscle Mitochondria Dysfunction [Study 27]
  1. Great video, thanks for explaining the study so clearly.

    Would you’d agree that this study shows exactly why it’s important for us to keep our fat inside adipocytes and avoid the insulin resistance causing cause them to leech out fat that causes havoc in other tissues?

    Given that palmitate is produced from excess carbs and those same carbs are implicated insulin resistance, would you concur that this study supports the argument that the standard American diet is detrimental to health and that a low carb diet is the way to go?

  2. Nic debate Barr Kay, this isnt going to blow over, because he's pointing out that you have no idea what you're talking about… if you think your smart enough to educate online, then you should be ready to back up what you preach…

  3. Any conclusion based ONLY in Macro nutrient factors and done in vitro with out measuring quality and nutrition value of whole of foods in humans means nothing to me… UV light oxides us as well… the same that oxygen at every moment … or mTOR pathways… ROS arguments are all empty for me.

  4. How does this concept of mitochondrial cell disfunction and cell death square with body builders eating significant quatities of red meat and its saturated fat? Body builders have been eating that way for decades and decades. How does this fit within a context of an athlete that burns fat for long endurance events in order to spare muscle glycogen? Prior to becoming "fat adapted" my muscles a didn't know what to do with fat. As a cyclist training upwards of 20 hrs a week I could never burn my belly fat or love handle. I was strong, but I ate a boat load of carbs. Since I've a drastically reduced carb intake 3.5 yrs ago, I'm a stronger, leaner athlete with seemingly "endless" ability to run… limited only by connecting tissue adaptations, rather than muscle fatigue. What do you think? Did the study use muscle tissue from a fat adapted, insulin sensitive person, or maybe from an insulin resistant person, or maybe a carb only fueling athlete. How do I fit into this paradigm? I'm certainly not wasting away. I'm very curious and wondering. I eat quite a bit of saturated fat, and honestly feel great, but I dunno. Thanks for your thoughts.

  5. so what this rodent study proves (if anything) is that rats are herbivorous, and thus do not share the same genetic adaptations humans do for safely consuming saturated fat.

    conclusion: rodent models are not appropriate for determining human nutrition, and any research attempting to make such parallels should be deemed invalid and irrelevant. good. not sure why your conclusion was different, perhaps you used the wrong slide? I'll assume so.

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