Saturday, May 28, 2022
Mitochondrial Health

Dr. Peter Adams | Cancer, Cellular Senescence & Senolytics



Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation.

In today’s episode, you will learn:
– Cellular Senescence and it’s dual role in protecting against cancer but also causing tissue aging
– The role of senolytic drugs to protect against age-associated cellular senesence
– The connection between the mitochondria and cellular senescence
– The Developmental theory of aging (Aging begins in the womb!)

If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.

All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams

Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast

Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium

Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld

PETER ADAMS LINKS:
Lab Website & Bio: http://www.padamslab.org/pages/members.html
Peter Adams Twitter: https://twitter.com/AdamsBioAging
Peter’s Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd

LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium

TIMESTAMPS:
00:00 Live Longer World
0:17 Peter Adams Intro
1:03 Cellular Senescence (& it’s dual role!)
12:47 Moles contain activated oncogenes
20:07 Senolytic Drugs: Should healthy middle-aged people take them?
25:38 Liver Cancer and Aging
35:53 Interferon Signaling & Immune System
36:54 Mitochondria & Cellular Senescence
41:53 Can Urolithin A clear senescent cells?
43:03 Chromostasis: Epigenetic Stability & Aging
55:01 Peter Adams interest in Cancer & Aging
1:00:33 Development & Aging (Aging begins in the womb!)
1:08:50 Aging is Universal. Let’s Unite in this Fight.

Episode Show Notes: https://livelongerworld.substack.com/p/padams

Thanks for watching & if you enjoy the episode, let’s spread the message on longevity. Aging is universal. Let’s unite in this fight.
Stay in good health – Aastha.

#cancer #senolytics #longevity #antiaging #aging #senescence

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