Sunday, February 5, 2023
Mitochondrial Health

More myth debunking: TMAO, Neu5gc, Methionine/Glycine balance

Throughout my training and practice as a physician, I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

00:03:10 Podcast begins

00:04:12 What is epidemiology, why is it useful, and when can we use it?

00:07:17 Vegetables + Cardiovascular disease

00:14:17 Interventional studies on vegetables

00:21:59 What is TMAO (Trimethylamine N-oxide)?

00:27:07 Choline and Carnitine

00:32:17 Mainstream literature regarding TMAO

00:35:37 TMAO in fish

00:42:05 What is Neu5gc?

00:50:40 Methionine + Glycine balance, should we worry about excess Methionine from animal foods? Should we supplement with Glycine?

01:05:55 Evolutionary consistency + how much protein should we eat?

Heart & Soil:
Animal-Based Gathering:


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47 thoughts on “More myth debunking: TMAO, Neu5gc, Methionine/Glycine balance
  1. Dude, the BioBank study is completely bogus. They're looking at daily vegetable intakes of on average less than three tablespoons of vegetables a day. They're not looking at any other dietary factor. When I eat potatoes I eat a couple pounds at a time. If I have broccoli it's always two full heads at a time with a can of black beans mixed in. A salad would fill the largest mixing bowl you own. I haven't had red meat since '79 and organ meats since '69. Why am I still alive? I ran 6km yesterday in windy 28dg weather wearing shorts and a light jacket. If it hadn't been windy I would have been bare chested. Your struggle with confirmation bias is astounding and is actually what holds my interest in your videos. I can't wait for the next one. 🙂

  2. Ohhhh yes, this is going to be a good one. Great job grouping all these closely related topics in one video, If anyone has similar grouping of these topics videos I am interested….thanks ✌️

  3. The increase in mRNA expression of FMO3 in Irs1/Irs2 knockout mice is one of the largest observed (Dong et al, J Clin Invest, 2006). The folks that research Irs1/Irs2 are more interested in glucose metabolism, so the link between TMAO and insulin resistance remains under-studied.

  4. You know what paul, I buy it! Glucose is essential for human life, so there isno way glucose could be harmful to human health, even then when you are having a bliod glucose of 20.

  5. Osteoporosis! MRI reveals my wife’s bones to look like swiss cheese. I am disgusted at how fast this came on. She had muscles and a strong back. Just withered away and lost 4” in height. She is almost 60. Please make a recommendation. Thank You Paul.

  6. Only recently started watching this channel. Would you consider discussing more about relocating to Costa Rica? I have been considering seriously a move from the US to Panama for quite a while. Interested in hearing more about this subject especially as it relates to trying to maintain a lifestyle as promoted by this channel or an above average healthy lifestyle in general. Thanks! Good info, the channel.has caused me to reconsider some dietary habits

  7. Seed questions. Seeds are bad. Yet fruit is good. Fruit contains seeds. I get that we shouldn’t eat the seeds. But avocados have large seeds. They wouldn’t be accidentally digested. What’s the evolutionary framework for the plant to entice us to eat it?

  8. Egg yolks question.
    Eggs are good. Chickens get fed corn soy etc. 1 stomach. Egg yolks are now bad. Due to the linoleic acid.

    Did I miss anything?

  9. That's why I eat ground beef and not steaks. It's cheaper and has better glycine to methionine ratio… I take also hydrolyzed beef collagen and take glycine powder. So I have at least 10-15g of glycine per day.. The glycine that you have from muscle meat is used up to metabolize excess of methionine and you can synthesize only like 3g of glycine, but you need much more for collagen synthesis and repair especially if you are big male and doing sports, have physical job etc.. That's why you need extra glycine outside of muscle meat.. We are 30% collagen. and around 30-35% of that collagen is glycine. So we need A LOT of glycine..

  10. Certain vegetables contain nitric oxide that helps us get oxygen into the bloodstream. Also certain plant foods have medicinal properties that can help us not get sick. The amount is the poison. Small amounts of vegetables per day is ok and actually beneficial.

  11. Subscribed. I like your message on long term ketosis being very bad for people. I had family members that were getting severely ill and didn't know why. It wasn't until i checked their diet and i found out they were on ketogenic diets. I pulled them out of ketosis by introducing fruits to their diet and lowering the fat and their health immediately improved. Now they stick to lean meats, fish, fruits and vegetables. Their health has never been better.

  12. please do an episode on FODMAPs. just found out (im 99.9% sure) that I'm terrible with fructans. Everything makes sense now. Who would've thought that wheat, beans, certain fruits (ripe bananas, grapefruit), dried fruit (raisins, not grapes) all have something in common?

    Science suggests most people who think they are gluten intolerant are actually just sensitive to fructans, which also means many other foods are problematic. I hear almost no one talking about this. Without knowing this, food sensitivities appear to be very random and difficult to pin down.

  13. Hey Paul, or anyone that wants to help, whenever I consume choline or even poor choline sources, I end up with terrible rubbery/fishy body odor. I also feel extremely foggy in my head. Taking riboflavin seems to sort of mitigate the brain fog and slightly reduces the dank body odor, but even eating liver can sometimes cause me to smell very bad. What is going on? I also seem to gain body fat when I consume choline.

  14. Paul can you do a similar analysis about uric acid which Rick Johnson points to as underlying cause of metabolic syndrome, hypertension and gout — and ties it to purines in small fish and red meat. FUD? I ask because it is opposite to my own N=1 experience with gout — which stopped in its tracks when I stopped all the vegetables, increased sardines and red meat (and left red wine and coffee constant — as one does 😏). I'm sure you could shed light on this. 🙏🙏🙏🙏

  15. Can we start seeing you take your supplements while you do these videos? Instead of just reading off customer’s comments. I want to see you take them on the video if you’re going to constantly promote your business. Tired of seeing health gurus talk about supplements but never show them taking it. Especially since most carnivore “experts” say you don’t need to take supplements. Plus, once you ground up the nutrients and dry them out they lose if not all their potency.

  16. Dr Paul, my you further explain relationship of insulin resistance and Apo B. My LDL & Apo B are elevated. triglycerides 44 HDL 60, fasting insulin-5 CRP- .4 I’ve been doing Keto/low carb for a few years now. Now I’m more carnivore-ish ! I’m reading the Carnivore code so I want you to elaborate for me! Thanks!

  17. Very glad to have Dr. Saladino doing all these youtubes debunking all the media and others touting misinformation. Thanks for going through all these studies and explaining it so well Paul. I listen to you now all the time now (as well as some other Keto/Carnivore Doctors).

  18. I've been recently following the channel and just want to say that every podcast was an eye-opener.
    In case you run out of subjects, please do a deep dive on the following topics:
    – fermented foods (vegetables, fruits, meat)
    – other foods that are produced by bees( royal jelly, pollen, propolis, bee bread)
    – what vegetables are ok for the proper human diet
    – Alternatives to grass-feed tallow (it is not easily available everywhere).
    – Cheatsheet for labs (both men and women)

    Thanks and good luck.

  19. I am constantly amazed at what I can do now that I prioritize protein. I did a full 10 hour day of going up and down a ladder to "spring clean" the garage rafters. Next day woke up a bit sore but knew that with my 1g:1lb protein intake would let me "get right back into the grind" and get in my morning 30min moderate full body workout I do 5-6 days a week. Felt great by the end of the workout! Unimaginable 3 years ago!

  20. Unfortunately for us Paul you will note get that many chances to debate the other side as they know how much knowledge you have, and would be unable to rebut your assertions – really enjoy this format and thanks.

  21. So I hit a plateau. I was frustrated that I wasn't losing weight as one gets. I had been eating meats and dairy and taking beef organ suppliments. This week I decided to get some carbs to experiment and got Pizza (a bad choice) and made some Beef tikka masala (basically 50% tomatoes.)
    Both of these things actually made my stomach hurt. I wanted to hurl after every meal. Just washed all the tomato crap off my beef and I'm finishing the last of the tikka masala sans veggies and oh my god I MISS BEEF SO MUCH. BEEF IS MY CAKE AND I'M EATING IT TOO!

  22. It's ironic for the 25 years I was a vegetarian, I could read substantial amounts by semi-professionals as to the efficacy of eating vegetarian. After I became desperate enough to become a carnivore in the age of the Internet, I can get all the latest research I want supporting the eating of meat. I'd prefer it if I could eat as much of anything I want, but it turns out I can only eat carnivore, to stay demonstrably healthy. I battle with myself over the science, but you seem to battle with everyone else, who isn't in this community. Sometimes I think the published papers of medical scientists read more like essays that science research.

  23. Now that David Perlmutter MD and Richard J. Johnson MD have released their books – Drop Acid (Uric Acid) and Nature Wants Us To Be Fat (no commercial relationship, just a reader) I would request that Paul does an in depth review of Fructose / Sucrose / Salt / Uric Acid / Urea / Vasopressin / the Polyol pathway (Glucose to Sorbitol to Fructose) in the context of the usual chronic diseases hypertension, NAFLD, CVD, T2D and dementia. Paul always states his endorsement of fruit and honey, and the non-issue of the fructose, however, countering some of DP and RJ hypothesises could form a very interesting part of one of these free form podcasts. Here's hoping, but in any event thanks for another stimulating discussion.

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