Wednesday, May 18, 2022
Mitochondrial Health

Citrate and Healthspan – improving cellular health



Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
https://www.jbc.org/article/S0021-9258(20)65025-6/fulltext
Plasma Citrate Homeostasis: How It Is Regulated; And Its Physiological and Clinical Implications. An Important, But Neglected, Relationship in Medicine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345696/
Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies
https://onlinelibrary.wiley.com/doi/10.1111/acel.13520
Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380630/
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13510

Erratum:
I have since producing the video noted that HIF does not directly cause the conversion of Citrate. Instead it reduces levels via PDK1 and shutting down the main mitochondrial Krebs cycle.

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