TUDCA – Tauroursodeoxycholic—Bile Acid It is a bile acid that is found in trace amounts in the human body. Bile acids are compounds released from the gallbladder that help digest fats.
Tauroursodeoxycholic acid (TUDCA) is a compound originally approved to treat liver diseases — but recent research suggests it may have a broader application.
Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of ursodeoxycholic acid (UDCA), which in contemporary pharmacology is approved by Food and Drug Administration (FDA) for treatment of primary biliary cholangitis. Interestingly, numerous recent studies demonstrate that mechanisms of TUDCA functioning extend beyond hepatobiliary disorders. Thus, TUDCA has been demonstrated to display potential therapeutic benefits in various models of many diseases such as diabetes, obesity, and neurodegenerative diseases, mostly due to its cytoprotective effect.
TUDCA has also been found to reduce oxidative stress, suppress apoptosis, and decrease inflammation.
A dose-response study of TUDCA tested doses of 500 mg, 1000 mg, and 1500 mg per day over six months, finding that there was little difference between the doses on liver marker.
1500 mg was the most effective at lowering enzyme levels while 500 mg was the most cost-effective.
In liver transplant patients, 500 mg of TUDCA taken daily for one year was not associated with any adverse effects.
In patients with PBC, 750 mg of TUDCA daily for two months was well-tolerated. Another study in patients with PBC found 1500 mg of TUDCA daily for six months was also well-tolerated.
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Dr. Jawad is a Board Certified Chiropractic Neurologist and Acupuncturist. In addition, a Diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner.
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