Wednesday, February 8, 2023
Mitochondrial Health

Saturated Fat: 2 Mechanisms of Insulin Resistance (and What it Could Mean for You)

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0:00 – Introduction
1:19 – Mechanisms of Insulin Resistance
1:46 – Mechanism 1: Oxidative Stress
3:32 – Mechanism 2: Ceramides
6:00 – Cautions & Take Aways

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#insulinresistance #diabeteseducation #healthyfats


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21 thoughts on “Saturated Fat: 2 Mechanisms of Insulin Resistance (and What it Could Mean for You)
  1. Nick, what are your thoughts on Unsaturated fat from an animal source? I just noticed in the shop various fatty cuts of meat from mangalita pigs.

  2. Nic, interesting video as allways. My main doubt about saturated vs unsaturated fats and health is the following… Let´s say SF really cause insulin resistance simply by exposure to cells, wouldn´t liberating fat from fat tissue when loosing weight imply greater insulin resistance in some cells since most human fat is a saturated like any animal fat? I know it´s quite a leap but I find really difficult to understand why saturated fat would have so bad effects in the human body if we are omnivores (or maybe those effects aren´t really that detrimental to health?)

  3. I happened to come across an old series you realised which looked at answering questions re lab values. I wonder if you could relaunch this series as you now have 1000s more followers full of questions for you! 😊

  4. Working with type 1 diabetics, I think you are off track a little. I have had T1Ds switch from a high saturated fat diet to a low saturated fat diet and the insulin sensitivity (as measured by grams of carbs covered by a unit of insulin) rises to typical levels within 3 days and plateaus there. When they go back on high saturated fat the physiological insulin "resistance" returns within less than a week. It also not progressive. Also, polyunsaturated fats actually carry oxygen radicals to the mitochondria, since they have many double bonds that oxygen can be added across. Saturated and monounsaturated fat do not, so even if saturated fatty acids somehow provoke free radicals, we do not know that this outweighs the oxidative damage carried by polyunsaturated fatty acids that are oxidized. I'll have to watch your first video. My theory would be that saturated fat is such a preferred fatty acid for energy (over damaging and inflammatory linoleic acid) that the muscle cells simply downregulate glucose burning enzymes when high SFA's are present, and the muscle cells also store free SFA's in place of some glycogen, but do not typically store PUFA's.

    Large herbivores like cows eat grass which is turned almost entirely into SFA's by their gut bacteria, which are then built up to make about 25% oleic, and 65% SFA's with almost no PUFA's. Why would an animal's biochemistry turn fiber into mostly SFA's and secondarily MUFA's with only small amounts of PUFA's if SFA's are not the best fatty acids to produce energy via beta oxidation? I'll go back and watch your first video but the general consensus I have seen among nutritional chemists is that PUFA's are horrible for mitochondria, readily carry oxidative and glycosylatative species, and that the linoleic in particular (which make up about 70% to 90% of PUFAs ingested are pro-inflammatory.

  5. Eating a diet high in animal fat has cured my diabetes and helped me lose 22 pounds in just 3 months. I've never felt better. Saturated fat is the best thing in the world. Saturated fat is 🧬

  6. Hi, kindly discuss SCADD, there is too little information about it, and which oil or fat is safe for people with this genetic defect.

  7. Very interesting mechanism Nic. I'm going to fall asleep thinking why the mitochondria would do such a thing. It must have a protective effect or else we will die right away instead of living longer (but not necessarily healthier). A quick search tells me that ceramides make up a great portion of our skin. So maybe the mitochondria is telling the body to produce more skin in order to store fat. The mitochondria is pretty smart. It doesn't want to kill it's host. At least not right away lol.

  8. Well, you started off by saying you are going to tell us the mechanism for why saturated fat is less than ideal, but then you didn't give the mechanism. In just one sentence you said "saturated fats seems to cause more ROS". That's a mechanism? I can't believe your explanation if you can't explain it. I'd suggest a drawing with the steps in the process and you should be able to show why unsaturated fat, excess glycogen, etc., are much less prone to produce ROS.

  9. I appreciate that you mentioned "if we can believe these studies" and whether they apply to humans and not just cells. For mechanism #2, since we do have an enzyme to produce Ceramides, I'm hard pressed to blame saturated fat for "too many Ceramides". The body has mechanisms and feedback loops to control this kind of thing, so one should ask what is the reason or the actual root cause of the cells in this study producing "too many Ceramides".

  10. Hi, Nic.
    Ceramides are useful topically, as in skin care. So far, so good for me; my diet is very low in saturated fat just because of my natural food preferences.(And I have a tub of ceramides in my bathroom.)
    Do you have a specific thesis or is this purely investigational?

  11. I wanted to mention that I think Dr. Gundry believes that the oxidative stress on the mitochondria from saturated fat and ketones actually stimulates mitochondrial proliferation which in the long run spreads out the workload and extends mitochondrial lifespan, as well as raising basal metabolism. PUFA's when oxidized in the bloodstream carry oxidative species that damage the cells of the vascular endothelium and probably instigate lesions that make the body release more LDL to repair the damage.

  12. @Physionic Ooh ooh ooh!!! Not 100% on topic but I'm curious about some rudimentary biochemistry. Let's say someone is on a ketogenic diet and producing ketones in a typical range, say 1.0 to 2.0 mmol/L… To be insulin resistant in such a state, insulin would have to be high, by definition. But if insulin is antagonistic to ketone production, how do we reconcile both states occurring in parallel?

  13. You are right again. Many people reversed diabetes type 2 and insulin resistance just eating whole foods with very low fat especially saturated

  14. I investigate nutritional approaches . Are you familiar with the work of Walter Kempner and Nathan Pritikin, Otto Hinrich Warburg? I think there was also a study on feeding herbivores and monkey saturated fat and that gave them heart disease. And I think those researchers in 30s, 40s up to 70s didn't corporation interest to make profits and to defend businesses. They were just trying to figure out how to reverse disease and the reasons for those diseases

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