Wednesday, July 6, 2022
Mitochondrial Health

Urolithin A – a useful chemical for mitochondrial health?



Join Dr. Van Dyken as she discussed the microbiome-produced chemical Urolithin A and. how it pertains to overall human health.

Timestamps:
00:00 introduction
00:16 What is Urolithin A and how is it made?
03:13 Reviewing the health benefits of Urolithin A
04:48 Urolithin A and the muscles
05:00 Urolithin A and the heart, blood vessels and endothelial health
05:47 Urolithin A and the brain
07:36 Urolithin A and the bones
07:48 Urolithin A and the GI tract
08:31 Urolithin A and the kidney
08:57 Urolithin A and metabolic diseases like obesity and diabetes
09:42 Human Studies

Video on Akkermansia mucinophila: https://youtu.be/9vqWr2JH8Yw

References cited:
1. “Immunomodulatory Role of Urolithin A on Metabolic Diseases – MDPI.” https://www.mdpi.com/2227-9059/9/2/192/htm
2. “Box-plots of urolithin concentrations ratios in blood cells related….” https://www.researchgate.net/figure/Box-plots-of-urolithin-concentrations-ratios-in-blood-cells-related-to-serum-after_fig3_339499547
3. “Effect of Urolithin A Supplementation on Muscle Endurance and ….” 19 Jan. 2022, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244
4. “The mitophagy activator urolithin A is safe and induces a molecular ….” 13 Jun. 2019, https://www.researchgate.net/profile/William-Blanco-Bose/publication/333789099_The_mitophagy_activator_urolithin_A_is_safe_and_induces_a_molecular_signature_of_improved_mitochondrial_and_cellular_health_in_humans/links/5edf353492851cf1386c0c55/The-mitophagy-activator-urolithin-A-is-safe-and-induces-a-molecular-signature-of-improved-mitochondrial-and-cellular-health-in-humans.pdf
5. “Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes.” 26 Nov. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705976/
7. “Impact of the Natural Compound Urolithin A on Health, Disease, and ….” https://www.sciencedirect.com/science/article/pii/S1471491421001180
8. “The gut microbiota metabolite urolithin A inhibits NF-κB activation in ….” 28 Mar. 2021, https://www.nature.com/articles/s41598-021-86514-6
9. “Urolithins: a Comprehensive Update on their Metabolism, Bioactivity ….” https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.202101019
10. “King’s Research Portal – King’s College London.” 24 May. 2018, https://kclpure.kcl.ac.uk/portal/files/96350797/Plasma_urolithin_metabolites_correlate_ISTAS_Publishedonline24May2018_GREEN_AAM.pdf
11. “Sectoral segmentation of retinal amyloid imaging in subjects with ….” 27 Sep. 2020, https://pubmed.ncbi.nlm.nih.gov/33015311/
12. “Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite ….” 22 Oct. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617978/
13. “Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit ….” https://pubmed.ncbi.nlm.nih.gov/26202092/
14. “Are mitophagy enhancers therapeutic targets for Alzheimer’s disease ….” https://www.sciencedirect.com/science/article/pii/S0753332222003079
15. “UA phase 1 study design, pharmacokinetic analysis and impact on ….” https://www.researchgate.net/figure/UA-phase-1-study-design-pharmacokinetic-analysis-and-impact-on-plasma-acylcarnitines-in_fig2_333789099
16. “Effect of Urolithin A Supplementation on Muscle Endurance and ….” 19 Jan. 2022, https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244

Urolithin A is a natural gut microbiome–derived food metabolite. It all starts when we eat a food that is high in Ellagitannins. These ellagitannins get converted to Ellagic acid in the small intestine. Ellagitannins and Ellagic acid are polyphenols that are present in highest concentrations in walnuts, pomegranates and berries. Microbes in our gut “digest” the ellagic acid and excrete the Urolithin A. Not just any microbe can metabolize Ellagic acid though, there are only a certain specialized few that can get the job done. Some of these microbes are Gordonibacter urolithinfaciens, Gordonibacter pamelaeae, Ellagibacter isourolithinifaciens, Bifidobacterium pseudocatenulatum, and one of my favorite microbes – Akkermansia mucinophila. There are some factors that seem to decrease our ability to produce Urothilin A from Ellagic acid: aging, body weight and overall health status.

Let’s review the benefits of urolithin A. The most consistent effect of Urolithin A is the improvement of mitochondrial health. It does this by recycling and clearing out dysfunctional mitochondria – this process is called mitophagy. The old, damaged mitochondria get recycled, and this leads to the generation of new mitochondria and improved cellular quality. As we get older, our ability to clear out the dysfunctional mitochondria is impaired, so being able to restore this process is a very promising strategy to counteract age related decline due to mitochondrial aging.

Another important benefit of Urolithin A is its anti-inflammatory properties.

source

Similar Posts

12 thoughts on “Urolithin A – a useful chemical for mitochondrial health?
  1. Do you know of any Oxalate intake issues related to Urolithin A? Raspberries, which I love, can create conditions leading to the development of calcium Oxalate urinary stones. Thanks 🙏

  2. Hello Dr. I love all your videos and information, this questions are not related to this topic but have you read the book of why animals don't get heart attacks but people do from Dr Matthias Rath and what is your opinion? Also your opinion or natural approach to IPF? Look forward to your comments. Thank-you

  3. Thank you, Dr. Van Dyken! You always make your information exciting and positive, giving us hope, and a smile! Things that we all need more of these days.
    Thank you for all you do and all you are! 😊

  4. Mega Giga Thank You Doc Van Dyken for insights much deeper than most doctors know. You are a GODsend to so many coming out of the Dark Ages. GOD Bless you and Russel as you bring much light to decades of darkness. glen North Dakota, USA!

Leave a Reply

Your email address will not be published.