Wednesday, July 6, 2022
Mitochondrial Health

Parkinson disease revisited, glut4, diabetes, neurogenesis, mitochondrial biogenesis



Parkinson disease is a/w diabetes. Substantia nigra cells have glucose type 4 (glut4) transporters; which means they are vulnerable to insulin resistance (IR). Glut 4 transporters are insulin dependent. Dopamine neurons in the SN have about 2 million mitochondria. They need lots of glucose. IR deprives these neurons of glucose. Lecture explains some pathophysiology of Parkinson’s, including an intro to the Braak hypothesis, leaky gut hypothesis, autoimmune hypothesis, metabolic hypothesis (with diabetes), pesticide hypothesis. Lecture explains how to promote neurogenesis and mitochondrial biogenesis. How to optimize blood flow to SN. Video mentions the work of the brilliant neurologist Alberto Espay MD, and his great book “Brain Fables,” but also explains that nutrition and exercise are under utilized to help Parkinson’s disease patients.

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6 thoughts on “Parkinson disease revisited, glut4, diabetes, neurogenesis, mitochondrial biogenesis
  1. I wonder if nicotinic acid or niacin would be helpful…since some think nicotine has some protective effect….also…if the brain loves this constant supply of glucose…especially when working hard…why is intermittent fasting or longer periods of water fasting supposed to be advantageous I wonder? And I think you must be right about galactose. I developed cataracts at a young age (50s)… while eating nonfat yogurt every day. When I went vegan they didn't go away but they didn't progress further. My different ophthalmologists over the years since then have said…you have the beginning of cataracts but they are too small to operate. Thank you, Doctor, for this informative video.

  2. People would be shocked to find out that their green tea is actually not good for them. You put a lot of work into your videos.

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