Tuesday, January 31, 2023
Mitochondrial Health

Pre fertilization DNA transfer to avoid mitochondrial disease inheritance appears safe

#fertilization #genetransfer #genomicdna #mitochondrialdiseases #eggs #embryonicstages #embryos #lifesciences #pregnancy #humanhealth #healthandmedicine

Transferring the nuclear genome from one egg into the cytoplasm of a donor egg is a strategy to enable women carrying mutations in their mitochondrial DNA to have healthy babies. A new study published in the open-access journal PLOS Biology, uses multiple “omics” techniques to show that this strategy, called spindle transfer, is likely to be safe, with little evidence of genetic or functional difference between the resulting embryos and healthy control in vitro fertilization (IVF) embryos. The results are likely to spur further adoption of spindle transfer for IVF when there is a risk of mitochondrial disease.

The “spindle” refers to the division apparatus that holds the nuclear chromosomes in suspension until fertilization. During spindle transfer, the maternal spindle is removed from an unfertilized egg and placed into a donor egg that has had its own spindle removed.Spindle transfer has been used clinically, but there remain questions about its safety.

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