Thursday, February 9, 2023
Mitochondrial Health

How Toxicants May Reduce Your Fertility and That of Your Children

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Can environmental toxicants reduce your fertility and that of your children? In this lecture of my course Diet and Gene Expression at Stanford Continuing Studies Course, Dr Carlos Guerrero Bosagna explains: how chemicals and food compounds can alter our hormonal balance thus impacting our metabolic and reproductive health. You will see how metabolism and reproduction are intimately connected and explore the role of mitochondria and epigenetics in this relationship.

I hope you enjoy this lecture!

00:00 Introduction: Dr Carlos Guerrero Bosagna
04:10 How Endocrine Disrupting Chemicals (EDCs) Can Affect Early Development
06:05 Epigenetics and DNA methylation
13:30 Environmental Epigenetics and Endocrine Disruptors
17:06 Reproductive and Metabolic Effects of Endocrine Disruptors: Obesity, Polycistic Ovary Syndrome (PCOS), reduced testosterone and sperm count
19:07 Phytoestrogens: Endocrine disruptors of natural origin
20:00 Babies eating soy formula: Possible effects on fertility?
23:00 Pesticides and sperm quality: Dose-dependent transgenerational epigenetic effects (Vinclonzolin)
27:15 Pesticides, Epigenetics and Ovaries: PCOS
31:07 “Hidden” transgenerational metabolic effects of EDCs: Obesity and fat accumulation
32:50 Effects of Stress on Early Metabolic Programming: Well-controlled studies in birds and chickens
35:30 Mitochondria as Molecular Link Between Metabolism and Fertility
37:03 Can we program mitochondrial function through epigenetics? Early stress, mitochondrial function, and epigenetics
43:58 Mitochondria as sensor of good and bad stress: Mitohormesis and Mitoflammation

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