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Some researchers think mitochondria could be hiding the key to Alzheimer’s disease. And we may have a new strategy to fight the threat that the global banana industry has been facing for decades.
Hosted by: Stefan Chin
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Sources:
https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024132/
https://www.science.org/content/article/new-universe-miniproteins-upending-cell-biology-and-genetics
https://dx.doi.org/10.1038/s41380-022-01769-3
https://www.eurekalert.org/news-releases/964920
https://www.eurekalert.org/news-releases/964675
https://dx.doi.org/10.1371/journal.pone.0273335
Images:
https://www.gettyimages.com/detail/photo/mitochondria-a-membrane-enclosed-cellular-royalty-free-image/1392927172?adppopup=true
https://commons.wikimedia.org/wiki/File:Mitochondrial_DNA_lg.jpg
https://www.gettyimages.com/detail/photo/mitochondria-royalty-free-image/846236786?adppopup=true
https://commons.wikimedia.org/wiki/File:MiRNA.svg
https://www.gettyimages.com/detail/illustration/structure-of-animal-cell-and-mitochondrion-royalty-free-illustration/1388619733?adppopup=true
https://www.gettyimages.com/detail/photo/of-the-patients-head-close-up-one-picture-from-the-royalty-free-image/1140748326?adppopup=true
https://www.gettyimages.com/detail/photo/banana-industry-royalty-free-image/1257613191?adppopup=true
https://www.gettyimages.com/detail/photo/banana-tree-with-bunch-of-growing-ripe-green-royalty-free-image/1157889543?adppopup=true
https://www.gettyimages.com/detail/photo/bananas-in-row-isolated-on-yellow-background-royalty-free-image/1332393262?adppopup=true
https://commons.wikimedia.org/wiki/File:Banana_wilt_(1919)_(20166670479).jpg
https://commons.wikimedia.org/wiki/File:Approximately_30_Gros_Michel_Bananas.jpg
https://www.gettyimages.com/detail/photo/banana-royalty-free-image/174959827?adppopup=true
https://commons.wikimedia.org/wiki/File:K7725-1-sm.jpg
https://www.gettyimages.com/detail/photo/banana-plantation-royalty-free-image/613215874?adppopup=true
https://www.gettyimages.com/detail/photo/organic-green-forest-of-banana-trees-with-bunch-of-royalty-free-image/905079548?adppopup=true
https://www.gettyimages.com/detail/photo/banana-fruit-muse-royalty-free-image/1286598533?adppopup=true
source
Head to https://linode.com/scishow to get a $100 60-day credit on a new Linode account. Linode offers simple, affordable, and accessible Linux cloud solutions and services.
They're turning the bananas autistic. =P
The variant of APOE – APOE4 – linked with nearly 2/3 of LOAD cases is a missense mutation that actually causes co-inherited impairments to the mitochondria via TOMM40. This is a further body of evidence suggesting that better research into multi-genetic inheritance can uncover the complex etiology of the heterogenous disease of Alzheimers.
I am apalled that you would accuse my bretheren and I of such a horrendous disease! Shame on you, Scishow!
You might do an episode on the ways risk is reported in biomedicine. I.E. Absolute risk (reduction/increase) vs relative risk (reduction/increase). Stating a gene increases risk by 20-50% is a meaningless statement at best and needlessly deceptive at worst without that concept applied to it.
Noticed you guys aren't popular in the algorithm anymore. Should change something you're doing to get more views and followers! Your content is too great!
Zac?
So what you're saying is:
You Schmoose, You Loose!
Yeah friend I'm now completely herpes negative with the help of herbs 🌿https://youtube.com/channel/UCS5h0JlgyiuTjgAe4hYt-LA
So you’re telling me… I’ve been lied to my whole LIFE?
Here in brazil we have at least 4 types of banana
There are actually a lot of sweeter species of bananas that would make great replacements! Check out weird fruit explorer❤
When I hear Mitochondria I think “is my count high enough? Can I perhaps be a Jedi?!”
… wait… that’s Midichlorian’s – never mind.
As a Brazilian, I still can't get over the fact that most of the world only knows one type of banana. And I hate that specific banana, despite loving others. There's two main types of banana that are common in supermarkets in Brazil. One more that is usually eaten cooked and just a bit harder to find, and two more that are unusual and I've personally tried before. There's probably more in other regions and we're not even close to the diversity found in Southeast Asia where bananas actually come from.
Came for Alzheimer's, left with bananas
Seems logical when you hear about the genius’s who passed on sleep most their life then lost their mind when they were real old….
The Golgi bodies are the postal service of the cell.
Geez ffs.. Alzheimer's is litterally diabetes type 3. Sure there might be a few cases out there that have other causes but the majority of Alzheimer's patients have simply eaten way to many carbohydrates in their life. Cut the carbs and just go regular senile when you get old. 😉
When I was young my brother told me that if I shmoose I lose. Ends up he was wrong, if you don't shmoose you lose.
Since mutations are more or less random can’t we use crispr to randomly change bits of banana dna to artificially derive a new variety?
Just bring back gros michel after making it resistant
See this is where we needed to have some gros Michelle's growing in a secure room somewhere
Who knew our trusty power-generating partners would one day backstab us?
Very interesting! Great sponsor too.
Linode FTW!!!
Wait!!! Are you saying… you Schmoose you loose??
I recently learned that I’m missing 2 proteins in my DNA. My oncologist discovered it after doing some genetic tests on the glioma removed from my head in 2021. We were told that it’s unheard of to be missing 2 proteins.. doesn’t even have a name yet!
I really hope that CRISPER can be used in the future to somehow put the proteins back into my DNA, but I know that it’s a long shot 😕
Interesting theoretical Alzheimer’s treatment tbh, just don’t give it to an ape
That's not quite true they're mutations in clones. They just tend to have a extremely low genetic diversity.
Alzheimers is caused by insulin resistance in the brain.
Good to know by the time I'm old enough to have problems with my shmoose I can probably get them fixed.
Could this work backwards? Could we dunk some of the remaining gros Michelle banana specimens into TR4 to try and make them resistant to original Panama disease?