In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue.
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
https://www.nature.com/articles/s41380-022-01769-3
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer’s and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen’s page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
*************************
Renue By Science 10% of all products: https://tinyurl.com/4yrf4tv3
10% off DoNotAge all products with discount code MODERNHEALTHSPAN
https://donotage.org/products/
10% Discount off all ProHealth longevity products: https://tinyurl.com/269hzbt7
If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
***************************************
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.
Audio Copyright Disclaimer
Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]
**************************************************
Other Supplements that we take
First thing in the morning
Vitamin C 1g – California Gold Nutrition https://iherb.co/tjmJCSKv
D3/K2 – Thorne – https://iherb.co/GYkP4T5b
Life Extension, BioActive, Folate & Vitamin B12, 90 Vegetarian Capsule https://iherb.co/viDytpH
Renue By Science, Liposomal CaAKG 90 300mg capsules – https://tinyurl.com/29j5pfcd
Renue By Science, Lipsomal Glutathione 90 130mg capsules – https://tinyurl.com/yc6dxk34
Equal Exchange, Organic Coffee, French Roast, Whole Bean, 10 oz (283.5 g)
https://iherb.co/hqfF23y
Midday
Renue By Science, Liposomal NMN 90 250 mg Capsules https://tinyurl.com/3wr8pr3t
Pure NMN Powder 100g https://tinyurl.com/ys4hxwyf
PURE Resveratrol Crystalline Powder (100 Grams) https://tinyurl.com/54dbnpmy
NOW Foods, TMG, 1,000 mg, 100 Tablets https://iherb.co/hjsroit
Celery Seed, 505 mg, 100 VegCaps https://iherb.co/BvKGp8p2
BioGaia, Osfortis with Vitamin D, 60 Capsules https://iherb.co/wJ14LbC
Life Extension, TMG Powder (Trimethylglycine), 1.76 oz (50 g) https://iherb.co/WG88uUZ
Celery Seed, 505 mg, 100 VegCaps https://iherb.co/BvKGp8p2
NOW Foods, Quercetin with Bromelain, 120 Veg Capsules https://iherb.co/8hbZ6DB
NOW Foods, Turmeric Curcumin, 60 Veg Capsules https://iherb.co/uwHg6SU
California Gold Nutrition, Immune 4, 60 Veggie Capsules (FIRST TIME BUY $1 – LIMITED OFFER)
https://iherb.co/xAL12AX
California Gold Nutrition, Lutein with Zeaxanthin, 20 mg, 60 Veggie Softgels
https://iherb.co/hHRwBE5
California Gold Nutrition, Astaxanthin, Astaliff® Pure Icelandic, 12 mg, 30 Veggie Softgels https://iherb.co/YqWcvJ3
NOW Foods, Ashwagandha, Standardized Extract, 450 mg, 90 Veg Capsules https://iherb.co/Hv2h2Jz
During the Day
Krill Oil – EPA/DHA – Bullet Proof Krill Oil – https://tinyurl.com/m64fwcsn – Please use code HEALTHSPAN15 at checkout
Bulletproof Innerfuel – https://shop.bulletproof.com/products/innerfuel – Please use code HEALTHSPAN15 at checkout
NOW Foods, Organic Acacia Pure Powder, 12 oz (340 g) https://iherb.co/wyfAnQi
NOW Foods, Psyllium Husk Powder, 12 oz (340 g) https://iherb.co/9kYZ7bg
Evening
Liposomal Apigenin – https://tinyurl.com/3esd726x
Liposomal HLA – https://tinyurl.com/4bhjfwc3
Magnesium Breakthrough – https://bit.ly/3O5tPfu
Life Extension, Melatonin, 3 mg, 60 Vegetarian Capsules https://iherb.co/Mbz2JxV
#DrCohen #peptides #mitochondria
source
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
Renue By Science 10% of all products: https://tinyurl.com/4yrf4tv3
DoNotAge 10% off all products Code MODERNHEALTHSPAN https://donotage.org/products/
Professor Cohen Playlist : https://tinyurl.com/34rc9ahz
Supergut product page: https://tinyurl.com/2h4v2v46
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% Discount off all ProHealth longevity products: https://tinyurl.com/269hzbt7
Bulletproof 15% off with coupon code: HEALTHSPAN15: https://bulletproof.fdf2.net/c/3176409/551222/9221
What are the best ways currently available/accessible to most people that can improve mitochondria function? (e.g. supplements, peptides, nutraceuticals, herbs, psychoactive compounds, meditation, infrared light therapy, etc etc)
How do we slow down this aging? Is there a way to increase mytophagy ?
Everyone seems to be studying senescence and senolytics – is anyone studying nutrients/drugs to assist with mitophagy – either removal of old mitochondria, their repair, or their biogenesis?
Thank you sir.
Check out MOTS-C and Humanin peptides for Mitochondrial and Human health benefits .. Both very exciting and indeed incredibly important metabolic regulators and indeed homeostasis promotional agents or compounds.
Given that chemical compounds accumulate differently in tissues, should we use a cocktail of chemicals to activate mitophagy in all tissues?
Thx Prof COHEN and Richard.
Thanks, Richard. A reminder to look back over notes on enhancing mitophagy.
Is it still considered true that mitochondria can be stimulated to increase in muscle cells by steady state anaerobic contraction (90 seconds or more)? This was asserted in Fred Hatfield's book "Scientific Bodybuilding."
4:20 … I believe Dr. Cohen misspoke when he said autophagy instead of apoptosis (programmed death of a cell)… autophagy is carried out by lysosomes, digesting damaged or non-functioning cellular components for energy. If such lysosomes digest a mitrochondria, that would be mitophagy. Anybody? Am I right here?
Does red light therapy increase the function of mitochondria?
Spermidine. https://www.youtube.com/watch?v=s_DqMZaLSSo
That mitochondria look different in different cells is raising my alarms about mitochondrial infusions, but so far all of the results look good, to the extent that it is near the top of my list for future treatments some day, assuming we can get the source figured out so that we aren't transplanting busted, short lifespan mitochondria.
Richard your hair is getting darker I think you're doing something right! Have you considered the TRIIM protocol?