Monday, December 4, 2023
Mitochondrial Health

E02 Marek Doyle Part 1: metabolic health, insulin dysfunction, mitochondria and organic acid testing

In this episode I speak with Marek Doyle, a functional nutritionist and metabolic health expert based in London, UK. Marek shares his experience working with over 3500 clients over the past 19 years. We talk about what it means to be metabolically healthy, insulin resistance as an adaptive state, the difference between insulin adaptation and dysfunction, the role of the mitochondria in insulin issues and the main drivers of mitochondrial dysfunction that Marek sees in practice including endotoxemia, liver issues and lifestyle factors. We finish off by talking about the organic acids test, and Marek shares some of the key markers that he looks out for when evaluating metabolic health using this test.

Find out more about Marek at where he runs a thriving practice as well as his Academy program for practitioner training.


2:47 What does it mean to be metabolically healthy
10:18 Insulin issues due to dysregulation + benefits of each state
13:30 Is insulin the reason why we get fat?
24:25 How to tell the difference between adaptation and dysfunction
28:13 Fructose good or bad?
37:26 Mitochondria, ETC and how do they affect insulin?
40:52 Oxidative stress – physiological and pathological
47:30 Main reasons behind mitochondrial dysfunction
1:04:26 Compound effects of liver issues
1:05:12 Organic acids test in evaluating metabolic issues
1:09:49 Growth and growing pains of organic acid testing
1:11:15 Differences between allopathic and naturopathic approaches


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