Friday, March 31, 2023
Mitochondrial Health

Electron Transport Chain | Mitochondrial Respiration | Biochemistry Basics

This video provides a tutorial on Electron Transport Chain. The electron transport chain occurs in the inner mitochondrial membrane. NADH is oxidized and transferred its electrons to complex I to coenzyme Q to complex III to Complex IV and finally to oxygen atom. Similarly, electrons from FADH2 are carried from complex II to coenzyme Q to complex III to cytochrome c to complex IV and finally oxygen. Oxygen is the final electron acceptor and reduces to water into mitochondrial matrix. When the electrons pass through complex I, III and IV, they liberate energy which is utilized to cause the conformation change and pass protons from the mitochondrial matrix to intermembrane space of the mitochondria. As a result, more protons are pumped out from the matrix to create the proton gradient, which is the driving force to synthesize ATP from ATP synthase enzyme.
The following topics are covered in this lesson,

1. Complex I – NADH dehydrogenase enzyme
2. Complex II – Succinate dehydrogenase
3. Complex III – Cytochrome bc1 complex
4. Cytochrome IV – Cytochrome c oxidase
5. Coenzyme Q or ubiquinone
6. Cytochrome c
7. Cellular respiration
8. NADH-ubiquinone oxidoreductase
9. Succinate-Q reductase
10. Ubiquinone-cytochrome c oxidoreductase
11. Q cycle
12. Proton gradient
13. Chemiosmotic hypothesis


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