Saturday, September 30, 2023
Mitochondrial Health

Dr. David Sinclair | TIME100 Summit – Updates on Latest Protocols 2023 – NOT a VEGAN! (Longevity)

Recently David Sinclair took part in the Time 100 Submit, in this clip David Sinclair was asked what were his latest Longevity/Anti-aging protocols.

Link to Full Clip:

Read more about the TIME100 Summit:

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Discovered by David Sinclair PhD, NMN or Nicotinamide Mononucleotide is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), NAD is found in nearly all our living cells. NAD is essential for sustaining life. Dr. David Sinclair (a professor at Harvard Medical School) once said if we suddenly didn’t have NAD we would be dead within eight seconds.’ Unfortunately, as we age our NAD levels drastically decline, clinical studies have shown that by age of 50 a typical person could have half the NAD+ they did in their youth and by the age of 80 our NAD+ (Nicotinamide Adenine Dinucleotide) levels drop to around 1% to 10% of those enjoyed in our youth. NAD is biologically unstable, which makes it unsuitable for oral supplementation. Fortunately, it is easy to restore our cellular NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which convert to NAD when it is in the cell. These NAD boosting supplements can be purchased from reputable companies such as Do Not Age, Renue by Science and Pro-health Longevity, however there are many unscrupulous companies selling fake NMN, so buyer beware. Dr. David Sinclair confirms that a fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, inflammation, DNA damage and failing mitochondria; all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan and Healthspan (health-span), so restoring NAD+ is increasingly being viewed as a scientific way to promote longevity and a way to combat the diseases of aging too. A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. In 2013 a scientific study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation, all are, on humans used as indicators of the aging process, they were then given NMN (Nicotinamide Mononucleotide) for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation. In human terms that would be comparable to a 75-year old having the results you would expect from a 25-year old. In a later methodical study, in 2018, again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed. The science showed that mice that were given NMN (Nicotinamide Mononucleotide) had restored blood vessel growth and had increased muscle endurance by up to 80%. Supplementation with NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) has been shown to slow cellular aging in mice and improve many metabolic defects common to degenerative processes, including muscle wastage, insulin resistance and inflammation. Nicotinamide mononucleotide (“NMN”, “NAMN”, and “β-NMN”) is a nucleotide derived from ribose and nicotinamide.
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9 thoughts on “Dr. David Sinclair | TIME100 Summit – Updates on Latest Protocols 2023 – NOT a VEGAN! (Longevity)
  1. If you are PLANT BASED ( A slick way of saying “vegan”), then you are going to be low on omega 3 fatty acids, B-12 vitamin, protein – especially creatinine which is important for the brain and muscles. Vegans are going to be low on astaxanthin which can be found in salmon. Good luck on your plant based diet because you are going to need. Veganism is almost like being a cult member of some kind of religion.

  2. Results published in 2012 from two major Harvard University studies—the Nurses’ Health Study, which followed the diets of about 120,000 30- to 55-year-old women starting in 1976, and the Health Professionals Follow-Up Study, which followed about 50,000 men aged 40 to 75—found that the consumption of both processed and unprocessed red meat appeared to be associated with an increased risk of dying from cancer and heart disease, as well as shortened life spans overall—a conclusion reached even after controlling for age, weight, alcohol consumption, exercise, smoking, family history, caloric intake, and even the intake of whole plant foods, such as whole grains, fruits, and vegetables. The findings suggest there may be something harmful in the meat itself.

    The largest study of diet and health was co-sponsored by the National Institutes of Health and the American Association of Retired Persons. Over a decade, researchers followed about 545,000 men and women aged 50 to 71 and came to the same conclusion as the Harvard researchers: Meat consumption was associated with increased risk of dying from cancer, dying from heart disease, and dying prematurely in general. Again, this was after controlling for other diet and lifestyle factors.

    Alzheimer’s disease risk may also be affected by meat consumption. In Japan, the prevalence of Alzheimer’s has shot up over the past few decades, thought to be due to the shift from a traditional rice-and-vegetable-based diet to one featuring triple the dairy and six times the meat. The lowest validated rates of Alzheimer’s disease in the world are found in rural India, where people tend to eat plant-based diets centered on grains and vegetables. In the United States, those who don’t eat meat (including poultry and fish) appear to cut their risk of developing dementia in half, and the longer meat is avoided, the lower dementia risk appears to fall.

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