Tuesday, September 26, 2023
Mitochondrial Health

MOTS-C peptide review – mitochondrial enhancer – amino asylum



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in this video, we review the peptide, MOTS-C, which is a mitochondrial enhancer to build muscle and burn fat

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MOTS-C (mitochondrial open-reading-frame of the twelve S rRNA-C) is a 16-amino-acid peptide that is naturally produced in your body by the mitochondria in your cells.

On a broader scale, the peptide is located in various organs of your body, such as the liver, brain, and muscle tissues.

Believe it or not, mitochondria have their OWN DNA, and within the “mitochondrial DNA” (mtDNA) are short open reading frames (sORFs) that can be used to encode and produce peptides.

In this sense, MOTS-C would be referred to as a “mitochondrial-derived peptide” (MDP).

(For more background information about mitochondria and the role they play in the body, read this slideshow presentation)

And as it turns out, MDPs like MOTS-C play significant roles in managing your metabolism:

“Considering that mitochondria are the single most important metabolic organelle, it is not surprising that these MDPs have metabolic actions. MOTS-c has been shown to target the skeletal muscle and enhance glucose metabolism.

As such, MOTS-c has implications in the regulation of obesity, diabetes, exercise, and longevity, representing an entirely novel mitochondrial signaling mechanism to regulate metabolism within and between cells”

MOTS-C has quite an interesting origin story, as its discovery was primarily implicated in treating obesity and diabetes:

“Research by Pinchas Cohen and his colleagues at the Leonard Davis School of Gerontology at the University of Southern California provides evidence that mitochondria play a key role in signaling and in energy production.

The first studies on MOTS-c were conducted on obese mice. They showed that the peptide helped boost glucose metabolism even when the mice were fed a high fat diet. These preliminary studies show evidence for improved control over blood sugar levels for those with type 2 diabetes and obesity”

All of this changed in 2015, when the media started hyping up MOTS-C as an “exercise in a bottle” peptide:

“Scientists at the USC Leonard Davis School of Gerontology have discovered a new hormone that fights the weight gain caused by a high-fat Western diet and normalizes the metabolism – effects commonly associated with exercising.

Hormones are molecules that act as the body’s signals, triggering various physiological responses. The newly discovered hormone, dubbed “MOTS-c,” primarily targets muscle tissue, where it restores insulin sensitivity, counteracting diet-induced and age-dependent insulin resistance.

…To test the effects of MOTS-c, the team injected the hormone into mice fed a high-fat diet, which typically causes them to grow obese and develop a resistance to insulin. The injections not only suppressed both effects in mice, they also reversed age-dependent insulin-resistance, a condition that precedes diabetes.”

So the idea is quite straightforward: Inject the MOTS-C peptide into your body and you can stimulate the positive changes induced by vigorous exercise!

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