Monday, September 25, 2023
Mitochondrial Health

Ep 93: How Cortisol Affects Your Mitochondria & Acute vs Chronic Stress (Stress & Mitochondria Pt 1)

Show Notes:
Free Energy Balance Mini-Course:
Jay’s Website:
Mike’s Website:

In this episode we discuss:
-Why stress is not your friend
-The effects of cortisol on your mitochondria
-Hans Selye’s general adaptation syndrome
-How cortisol causes mitochondrial dysfunction, heart disease, insulin resistance, autoimmunity, allergies & hypersensitivity, mineral imbalances, and cancer metabolism
-Why acute stress does not lead to improved health via hormesis

0:00 – intro
1:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance
20:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response
28:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts
31:04 – how long-term stress causes degeneration
31:55 – functions of the mitochondria
35:54 – mitochondria upregulate energy production in response to stress
38:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)
41:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time
47:30 – how mitochondria respond to excess stress and how this relates to fat gain
56:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism

​​To see the studies and articles referenced throughout this episode, check out the show notes at

Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.


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