Thursday, September 21, 2023
Mitochondrial Health

Ep. 95: Hypothyroidism In Context & Thyroid Hormone Basics (Hypothyroidism Part 1)

Show Notes:
Free Energy Balance Mini-Course:
Jay’s Website:
Mike’s Website:

In this episode we discuss:
-Why hypothyroidism is not the root cause of your issues
-Why TSH on its own is not a good marker of thyroid status
-The importance of thyroid hormones for sex hormone production, gut health, and immune function
-T3’s effects on autophagy, mitochondrial biogenesis, and uncoupling
-Whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

0:00 – intro
1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism
9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state
12:45 – why hypothyroidism is not the root cause
16:23 – the basics of the different thyroid hormones and their regulation
19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops
24:45 – the basics of thyroid hormone production
29:37 – the basics of thyroid hormone conversion
35:17 – the larger context of thyroid hormone production and conversion
38:58 – the basics of thyroid hormone transport
41:44 – the basics of thyroid hormone uptake
46:23 – the nutrients involved in thyroid hormone production and conversion
50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol)
57:29 – the effects of T3 on gut health, immune function, and aging
1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign
1:08:41 – the relationship between vitamin A and thyroid hormones

​​To see the studies and articles referenced throughout this episode, check out the show notes at

Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.


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11 thoughts on “Ep. 95: Hypothyroidism In Context & Thyroid Hormone Basics (Hypothyroidism Part 1)
  1. Such an informative episode. I was diagnosed in 2005 with Graves Disease. But in the last two years it has gone hypo due to the stress of my sisters death and then my husband with stage 4 cancer. I am working with a Naturopath, and I have been on Armour since April. However I am still having the same symptoms. (Except my sleep is better) She has not tested my rT3 and I think maybe she should. I have been wondering if maybe the thyroid is too much right now being I was also on low carb/carnivore/keto diet along with IF, but had stopped it a couple of years ago. I still struggle to stop the IF though. I had also under eaten and yo-yo dieted for decades. I wish I had this information when I was in my 20's.

  2. Can I request a topic for a future video?

    Bioenergetic fat loss case studies based on your respective coaching practices would be so awesome to see.
    I know Jay has one testimonial on his website, where a guy lost significant weight.

    I still can't figure out what that looks like in practice, in terms of lifestyle changes, if one is to pull it off without a caloric deficit, but rather by moving more and eating more.
    Unless we are talking military bootcamp, rucking and eating tons of fibrous foods, I don't see how it can add up.

  3. Awesome stuff Jay and Mike.

    My TSH was slowly rising from the ages of 17 to 21 until it was about 2.5, and that was about the worst I ever felt. After finding Rays work at 24 I improved quite a lot for a couple of years along with your help as well. I then started taking thyroid for a few months and got my waking temps up to about 36.4 Celsius. My TSH went up to about 3.4! And that was the best I had felt in years. I strongly suspect (although I have no blood work) that it would have been suppressed in the meantime.

  4. Love that you guys are fixing people's issues with a Ray Peat inspired philosophy. So many think they can eat copious amounts of sugar and ice cream and then complain that "Ray Peat diet" doesn't work. U guys are proving that, properly understood, it does.

  5. really appreciate the info. Low T3 has been a problem I've been trying to figure out for years now, got a more nuanced understanding of thyroid hormones and their mechanisms here than anywhere else I've yet to see.

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