Friday, September 22, 2023
Mitochondrial Health

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Here are some sources that support the definition of mitochondrial biogenesis as the process of increasing the number and size of mitochondria in muscle cells and the involvement of the PGC-1α and AMPK pathways:

Hood DA, Memme JM, Oliveira AN, Triolo M. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Annu Rev Physiol. 2019;81:19-41. doi: 10.1146/annurev-physiol-020518-114310

Holloszy JO. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem. 1967;242(9):2278-2282.

Hood DA. Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol. 2001;90(3):1137-1157. doi: 10.1152/jappl.2001.90.3.1137

Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol Endocrinol Metab. 1999;277(1):E1-E10. doi: 10.1152/ajpendo.1999.277.1.E1

Handschin C, Spiegelman BM. The role of exercise and PGC1α in inflammation and chronic disease. Nature. 2008;454(7203):463-469. doi: 10.1038/nature07206


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