In this episode of the Timepie Lecture Series, Dr. Julie Andersen presents us with an overview of the essential details concerning neurodegenerative disorders like Alzheimer’s and Parkinson’s, their correlation with the aging process, and effective preventive approaches. Furthermore, she expounded upon her vision for the future of aging research and these age-related diseases.
Dr. Andersen received her PhD from the Department of Biological Chemistry in the David Geffen School of Medicine at the University of California, Los Angeles, and received additional research training in the Department of Neurogenetics at Massachusetts General Hospital in Boston. She joined the Buck Institute, the first independent biomedical research institute focused solely on aging, in 2000. She has published more than 170 scientific papers, holds three current patents and won a Parkinson’s Pioneer Award from the National Parkinson’s Foundation.
Contact Dr. Julie:
https://www.buckinstitute.org/lab/andersen-lab/
00:00 Greeting and Introduction
01:30 Expectations for the clinical application of taurine
06:14 Symptoms, risks, and vulnerable population of Parkinson’s
10:36 A genetic view of developing Parkinson’s
11:38 The role of the environment plays in the neurodegenerative disease
14:15 Effects of aging and the efficacy of senolytics on the brain
16:28 Using senolytics to treat Alzheimer’s
18:28 Develop cellular delivery systems targeting the pathology without damaging health cells
20:00 Paraquat and other substances that cause aging and cognitive disease
24:20 Drugs given to animal models to treat the disease
30:09 How do people with the APOE-4 gene avoid dementia and cognitive decline?
35:24 Benefits of Urolithin A and enhancing gut microbiome function to improve brain health
39:52 Safe use of Lithium to treat Alzheimer’s disease
41:03 Potential of Rapamycin, calorie restriction, and other anti-aging intervention for brain health
46:13 Suggestions of food, drink, and supplements for prevention
47:30 Opinions toward the first FDA-approved beta-amyloid antibody drug
52:33 Detections to forecast the neurodegenerative disease
54:07 Vision of future anti-aging science and conclusion
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