Dr. Sandra Kaufmann talks about the important role of SIRT3, a sirtuin which promote longevity and mitochondrial Health. Also her top 3 SIRT3 activators in this short clip.
https://www.frontiersin.org/articles/10.3389/fnagi.2013.00048/full
https://www.sciencedirect.com/science/article/abs/pii/S0531556503002092?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121285/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567935/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406297/#B74-cells-11-02596
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317077/
https://www.sciencedirect.com/science/article/pii/S2211383522003331
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The video explains how SIRT3, a protein that promotes longevity and mitochondrial health, can be activated. SIRT3 removes acetyl groups from proteins, thereby turning on at least 84 mitochondrial proteins, which improves mitochondrial function. Low SIRT3 levels lead to losing over 10% of the process. Energy-demanding organs like the brain, heart, and muscles suffer as we age. Therefore, activating SIRT3 is significantly vital since it declines after age 30 and is very low by 60.
There are three natural SIRT3 activators that you should know about:
1) Resveratrol, found in grapes
2) Dihydromyricetin in Hovenia fruit helps liver health and hangovers!
3) Melatonin, which has evolved with mitochondria over thousands of years to activate SIRT3
SIRT3 requires NAD+, so NAD+ precursors are also essential. Other mitochondria helpers include activating NRF2 antioxidants and blocking the mitochondrial transition pore. Astaxanthin is a favourite antioxidant as it's the best free radical scavenger.
In conclusion, SIRT3 is critical to longevity and can be activated naturally using specific compounds. Supporting NAD+, antioxidants, and mitochondrial function can also help improve health.
I do think SIRT3 is the most important sirtuin, just not many people talk about it!
Thank goodness for RAR to introduce Dr. Kaufmann; she is amazing. If only all MD's had this knowledge and wisdom.
It would be great to know how much melatonin and when to take it. Thank you for a great video.
This is all very interesting but . . .
NONE OF THESE CHEMICALS can account for the health and longevity of the thousands (probably millions, actually) of centenarians around the world who have lived WITHOUT taking a single one of them during their long lifetimes. Neither economic prosperity nor the artificial products of organic chemistry can substitute for good genes and/or a "healthy" diet and lifestyle . . . at least not yet.
Is melatonin from supplements as effective as from sleep? What might be some suggested daily dosages.
the myrecetin is interesting, thank yuo.
But about melatonin: hasn't it been shown that external melatonin does not reach the mitochondria? thanks
great content!