Why is Everyone Taking GlyNAC?

5 thoughts on “Why is Everyone Taking GlyNAC?”

1. I just turned 66 and have been taking GlyNAC for a couple of months now. About four grams a day divided into morning and evening. Due to the fact that I've also been taking NMN for over a year now, along with other supplements to support that, I can't say that I've seen any major differences except for one. My mood has stabilized and I've become calmer. NMN did that also but GlyNAC has taken it down another notch as well. Noticed it right away. I work in a job that can produce a lot of stress at times. Now I find that, while I still do experience some stress , the intensity of it is much lower. It's funny because after a lifetime of getting all worked up about things that when it doesn't happen my brain gets confused. It wants to get all agro but can't and it actually feels somewhat disappointing. I wouldn't have it any other way and maybe someday that feeling will go away.

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2. Thanks for the GlyNAC overview video. In addition to the study reviewed in this video, the Baylor researchers have done a number of similar studies, including a study focused on cognitive benefits from taking GlyNAC, which are as impressive as the cellular and physical functioning benefits. All these studies have provided the same pattern of benefits and GlyNAC — at the relatively high doses used in the studies — has been safe and effective. My wife and I have been taking GlyNAC daily for about 6 months (late 50s and mid-60s ages). We see clear functional benefits, including exercise performance, reduced exercise-induced muscle pain, increased metabolism, reduced/eliminated joint pain, skin improvements, and others improvements specific to each of our health issues. The changes come on fast, but aging takes a long time to come on, and deep regeneration (cellular cleanup, rebuilding, and generation of new cells) will likely take longterm steady application. We have no plans of stopping GlyNAC. Our occasional lapses in taking the supplement for a few days have resulted in re-emergence of symptoms… natural A/B experiments. The symptoms resolve after resuming GlyNAC in a day or two.

   About dosing. I disagree with your recommendations, JT. NAC has especially low bioavailability, with less than 10% being available in the bloodstream (perhaps as low as 6%). First pass elimination in the small intestine and liver binds most of it. But there are limits to the capacity of this binding process, and some evidence indicates that higher doses result in more than linear increases in bioavailability. Consequently, lower doses have far less effect. Take for example, the large Nestle study of GlyNAC. It was a 2-week study, which should have been long enough to observe statistically significant (and functional) improvements — as seen in the Baylor studies. More study participants (10X the Baylor studies) should have made it easier to detect changes. But there were no effects for the 114 people in the study. Why? First, the dosage ranged from 1.2 to 3.6 grams of Gly and the same amount of NAC. This is a much lower dose than the Baylor studies, where a 110 pound person would take 5g each. Second, the Nestle study split the doses in half, and took them 2x per day. So, the max dose people were taking was 1.8 grams each in one go. Compared to 5 grams each (and more by weight) in the Baylor studies. It is likely that first pass elimination resulted in very little NAC making it through the bloodstream to the cells in the Nestle study. Nestle did do a secondary analysis of people with the lowest glutathione levels, and in this subgroup, there were some measurable benefits.

   I conclude that either the Baylor study participants were less healthy (a lot more glutathione deficient) than the Swiss participants, or the Nestle study dosage was simply too low to show broad benefit in only 2 weeks. NOTE: taking the Baylor study dosage, my wife and I did see benefit in 2 weeks.

   We take our GlyNAC in one daily dose. We try to take it 30 minutes before a meal or 2 hours afterward. But we don't let this be a rigid rule… taking it anytime seems to work fine. The Baylor research used 1 gram each per about every 22 lbs (10kg) of body weight. So, a 220 lbs person would take 10 grams each, and a 110 lbs person 5 grams each. I've migrated down from 8 grams each to 5 grams each, most days. When I've been under a lot of physical, mental, emotional stress, I go back up to 8 grams. No negative side effects for either of us. To save money, we've been taking powdered Gly and NAC with lots of water. The worst side effect: NAC stinks like sulfur and tastes rotten… at least for me — that's why I reduced my dose: in a large glass I can dilute the mix with water enough to reduce the sulfur taste. We disguise the flavor with lime juice… and that helps. But given the positive effects, I'll hold my nose and keep going.

   Some people should NOT take GlyNAC. Start with a low dose to make sure you don't have a rare allergy. Don't take it if you take nitro. And consult your MD if you are on blood thinners… and when in doubt, always consult with your doctor.

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3. I'm 65 and became interested in these precursors to improve liver function, which appears to have worked. 2 years ago, I was plagued with cramps and fatigue. D3 was another element of my recovery. I'm now supplementing heavily with a much wider range of vitamins, chelated minerals, aminos, berberine, Taurine, R-ALA and a lot more. I have felt better and better. In my case, it seems I was depleted in many things. But these two were the first, and made an obvious difference.

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4. You sound just like that guy who puts on makeup and talks to children…I see him on Odins Men sometimes. You look like him too. Have you heard that before?

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5. love the spongebob memes

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