Thursday, June 20, 2024
Mitochondrial Health

#30 – Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?

Original release date: 11/26/18

In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.

We discuss:
-How Tom got interested in cancer research [9:00];
-Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
-Otto Warburg and the Warburg effect [30:45];
-Germline mutations, somatic mutations, and no mutations [42:00];
-Mitochondrial substrate level phosphorylation: Warburg’s missing link [51:30];
-What is the structural defect in the mitochondria in cancer? [1:02:00];
-Peter’s near-death experience with the insulin suppression test while in ketosis [1:06:30];
-Insulin potentiation therapy and glutamine inhibition [1:13:15];
-The macrophage fusion-hybrid theory of metastasis [1:39:30];
-How are cancer cells growth dysregulated without a mutation? [1:47:00];
-What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
-How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
-Case studies of GBM survivors [2:32:45]; and

Show notes page:

The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 10 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is the founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. The practice applies nutritional biochemistry, exercise physiology, sleep physiology, techniques to increase distress tolerance, lipidology, pharmacology, and four-system endocrinology to increase lifespan (delaying the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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