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Depletion of ATP, Damage to Mitochondria, Influx of Calcium are explained. The most important targets of injurious stimuli are (1) mitochondria, the sites of ATP generation; (2) cell membranes, on which the ionic and osmotic homeostasis of the cell and its organelles depends; (3) protein synthesis; (4) the cytoskeleton; and (5) the genetic apparatus of the cell.
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017.
Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014.
