Alan Green, MD has been using low-dose rapamycin in his clinical practice for years, we discuss the potential health benefits and ways this can be used as a tool to support healthspan.
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Connect with Dr. Green: https://rapamycintherapy.com/
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0:00 Intro
5:05 Rapamycin stops this deterioration and the development of dementia.
9:47 Pharmaceuticals do not treat end-stage disease.
11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases.
19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan.
24:40 Ageing is a programed genetic timebomb.
30:50 Slowing mTOR with rapamycin slows ageing.
37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high.
40:18 Once a week dosing gives a high level at the beginning of the week to knock out mTOR1 and it was low enough at the end of the week to not interfere with mTOR2.
41:15 Reducing mTOR1 reduces the activity of the innate immune system.
42:45 Decreasing the innate immune system is good for stopping chronic inflammation and age-related diseases.
48:30 A typical dose is 6 mg. It is less for a smaller healthy person.
50:17 Rapamycin is good for sports performance because it is good for cardiac performance.
54:10 Rapamycin helps maintain strength and quality of muscles.
55:30 Bodybuilders do not benefit from rapamycin.
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