Six mitochondrial genes represented within the 22q11.2 genomic region can affect different aspects of mitochondrial function, such as ATP synthesis, calcium regulation, redox balance, fatty acid metabolism, and trafficking. These defects give rise to defects in synaptic and neural circuit function, which underlie neuropsychiatric disease, as explained by Prakash Devaraju.
Read the full article in BioEssays here: http://onlinelibrary.wiley.com/doi/10.1002/bies.201600177/full
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