#feedbackinhibition #biochemicalpathways #biologymetabolism
https://gotopnews.com/post/1354041
Why is the answer with cells and extension people? The answer may have a lot to do with the organelles that provide energy. Although this idea is not new, the evidence was missing directly in human cells. In study Communications Biology on January 12th, team managed by the researchers of Columbia University discovered that human cells that are corrupt mitochondria react to higher gear and spend more energy.Comes at high cost: dramatic increase in the aging rate of cells. “Findings have been made in cells obtained from patients with rare mitochondrial diseases, but it may have anything to do with other conditions affecting mitochondria, including neurodegenerative diseases, inflammatory conditions and infections, Mart says Martin Picard, Doctoral Professor, Behavioral Professor, Professorcolumbia University Vagelos Doctors and Surgeons College.. “In addition, hypermethabolism may be an important reason for the worsening of most cells as they get older.” Hypermethabolic cells age faster Generally, it was assumed that mitochondrial defects to slow down their metabolic rates by effort to energy protection. However, by analyzing metabolic activity and energy consumption in cells with diseases, researchers found that mitochondria deteriorated cells have doubled energy.Re -analyzing data hundreds of patients with mitochondrial diseases has shown that defects also increase cost living at entire body level. “When cells spend more energy to make proteins and other substances necessary for short -term survival, they probably steal resources from processes that provide long -term survival processes.” Although this increase in energy continues to operate cells, it disrupts the cells of cell and activates stress response and inflammation.Net Effect accelerates biological aging. “When cells spend more energy to make proteins and other substances necessary for short survival, they are probably stealing resources from long -term survival processes such as protecting telomeres,” he says. Mitochondrial defects caused by rare genetic mutations cause human cells to increase their metabolism. Although this helps to survive for short time, it comes at a high cost: dramatic increase in the aging rate of cells. Hipermetabolism may be an important reason for the deterioration of most cells as everyone ages.Picard provided by Columbia University Irving Medical Center. Hypermethabolism, fatigue and aging This hypermetabolic condition can explain why people with mitochondrial diseases experience fatigue and intolerance exercise as well as other symptoms.says Picard. The study does not point to new drugs for patients with mitochondrial diseases that are currently untreated, but it strengthens the existing suggestions for more movement of patients.“However, exercise is known to increase the effectiveness of an organism. For example, a person who uses less energy than someone who is physically active to maintain basic physical processes.” Improving efficiency of the organism that will reduce energy use in cells and improve fatigue and other symptoms can partially explain health benefits of exercise in patients with mitochondrial diseases. Picard, in search of new treatments for mitochondrial diseases, researchers should focus on hyper metabolism.We need more research to know if it will work.” Hypermethabolism is also common for other diseases. If cellular energy expenditure plays a causal role in directing the aging process, targeting hyper metabolism can improve fatigue, improve quality of life of people and even slow down biological aging.
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Biological aging due to an extreme active cell metabolism
