The second dose of the COVID-19 Pfizer vaccine seems to bring more symptoms. One of the most common being fever and chills. What is the neuroscience behind this response?
Yamato M, Kataoka Y. Fatigue sensation following peripheral viral infection is triggered by neuroinflammation: who will answer these questions?. Neural Regen Res [serial online] 2015 [cited 2021 Jan 15];10:203-4. Available from: http://www.nrronline.org/text.asp?2015/10/2/203/152369
Evans, Sharon S et al. “Fever and the thermal regulation of immunity: the immune system feels the heat.” Nature reviews. Immunology vol. 15,6 (2015): 335-49. doi:10.1038/nri3843
https://www.health.harvard.edu/a_to_z/fever-a-to-z#:~:text=Fever%20develops%20when%20the%20hypothalamus,inside%20the%20body%20(internal).
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