Dr David Sinclair’s lab is collaborating with many other labs working towards the same goal to slow down and even reverse human aging. In this 2021 presentation, Dr Sinclair presents the newest approaches on this. The Main topics are:-
. Epigenetic Reprogramming with OSK 3 Yamanaka Genes – Oct4, Sox2, Klf4 which resetting the gene expression from an old to young state without losing the identity of human cells.
. A more rapid & inexpensive biological age test – ScAge using new predicting age process “Shallow TIME-Seq process” It has potential to measure million of people in a predictable time frame.
. Human Tissue Reprogrammed with iPSCs(induced pluripotent stem cells)., targeting reverse aging especially alzheimer’s disease.
. Epigenetic Noise driven by double strand breaks .
. BioScience, a company co-founded by Dr Sinclair, 3 core platform technologies – Mitochondrial Uncoupling, Chaperone-Mediated Autophagy & Epigenetic Reprogramming
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
Dr Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.
Dr Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.
He is also co-founder and co-chief editor of the journal Aging. He is an inventor on 35 patents and has received more than 35 awards and honors. In 2014, he was on Time Magazine’s list of the “100 Most Influential People in the World,” and listed as Time’s Top 50 in healthcare in 2018.
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