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In this episode of The Alpha Human Podcast, Lawrence delves into drugs that can trigger ferroptosis to kill cancer cells. Ferroptosis is a regulated form of cell death characterized by the accumulation of lipid peroxides and iron-dependent reactive oxygen species, as this can be an Achilles’ heel for cancers that exhibit iron overload.
Although there are currently no approved drugs designed for this purpose, there are a number of existing pharmaceuticals that have demonstrated the ability to incite ferroptosis in cancer cells.
For instance, Lawrence highlights Auranofin, a rheumatoid arthritis drug, and Metformin, a widely prescribed drug for diabetes that has also shown potential for inhibiting cancer invasion and metastasis. Both drugs have demonstrated the ability to induce ferroptotic death in cancer cells.
Additionally, Lawrence discusses the effectiveness of Artesunate, a derivative of artemisinin commonly prescribed as an anti-malarial drug, and Sulfasalazine, primarily used for treating inflammatory bowel diseases like ulcerative colitis, as both have shown the capability to trigger ferroptosis as well.
Targeting glutamine metabolism as a therapeutic strategy for cancer
https://www.nature.com/articles/s12276-023-00971-9
A Promising Future of Ferroptosis in Tumor Therapy
https://www.frontiersin.org/articles/10.3389/fcell.2021.629150/full#B134
Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525071/
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
https://www.frontiersin.org/articles/10.3389/fphar.2018.01371/full
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00253-0
Mechanisms of metformin inhibiting cancer invasion and migration:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540116/
Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727937/
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines
https://www.nature.com/articles/s41419-021-03998-w
Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blockage in K7M2 osteosarcoma cells
https://academic.oup.com/metallomics/article-abstract/14/5/mfac027/6571254
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
https://www.oncotarget.com/article/8651/text/#F2
Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor
https://www.spandidos-publications.com/or/42/2/826
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026986/#CR25
Identification of Artesunate as a specific activator of ferroptosis in pancreatic cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468338/
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells
https://www.sciencedirect.com/science/article/pii/S134786132200007X
Artesunate Inhibits the Growth Behavior of Docetaxel-Resistant Prostate Cancer Cells
https://www.frontiersin.org/articles/10.3389/fonc.2022.789284/full
Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692972/
#cancer #kidneycancer #fightcancer #killcancer #chromophobe
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