Show Notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/
Free Energy Balance Mini-Course: https://jayfeldmanwellness.com/energy
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Jay’s Website: https://jayfeldmanwellness.com/
Mike’s Website: https://mikefavenp.com/
In this episode we discuss:
-Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
-The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response
-How stress prevents our mitochondria from effectively producing energy
-How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease
-How sugar and fat cravings result from stress and why listening to them is beneficial
-How adaptations to stress get passed on through generations
0:00 – intro
2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids
6:05 – the short-term effects of catecholamines
8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
14:40 – the protective effects of uncoupling as a part of the stress response
20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response
37:33 – the effect of acute stress on energy production in mitochondria
45:18– the effect of chronic stress on energy production in mitochondria
48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states
56:12 – the effect of chronic stress on appetite, cravings for sugar and fats, and binging, and why consuming carbs and fats doesn’t cause fat gain
1:05:24 – the relationship between mental health, mood, and metabolic function
1:10:21 – how adaptations to stress get passed on through mitochondrial DNA
1:18:32 – how to best improve mitochondrial function and our health
To see the studies and articles referenced throughout this episode, check out the show notes at https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/
Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.
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