#Diabetes #BloodGlucoseRegulation #Insulin
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In this 2nd part of Dr. Najeeb’s webinar on the glucose regulation in fed state, he explains in detail the insulin signalling pathways and the action of insulin on hepatocytes in the well-fed state. He also discusses the various mechanism through which glucose is processes inside a liver cell and the synthesis of triglycerides from the excessive glucose. At the end, he manages to outline the steps through which the newly formed triacylglycerol molecules are packaged and then transported out the hepatocytes.
Time stamps:
• Insulin receptor signalling pathway
00:00:00 – 00:26:30
• GLUT transporters and their significance
00:26:30 – 00:33:15
• Role of glucokinase and its regulation
00:33:15 – 00:38:28
• Role of glucose 6-phosphatase and its regulation
00:38:28 – 00:44:30
• Glycogenesis in fed state and its regulatory enzymes
00:44:30 – 00:55:45
• Pentose phosphate pathway and its regulatory enzymes
00:55:45 – 01:01:07
• Glycolysis and its regulatory enzymes
01:01:07 – 01:08:00
• TCA cycle and its regulation
01:09:00 – 01:18:04
• Inhibition of isocitrate dehydrogenase and its significance
01:19:55 – 01:22:35
• Citrate – Malate Shuttle
01:22:35 – 01:26:30
• Acetyl CoA carboxylase and its regulation
01:26:30 – 01:31:05
• Fatty acid synthase and its regulation
01:31:05 – 01:37:03
• Transport of triglycerides out of liver
01:37:03 – END
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