Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions.
📍What Richard Johnson, MD, & Rob Lustig, MD, discuss:
00:00 — Intro
10:17 — Fructose is the driver of some diseases that are on the rise in kids
12:16 — Fructose is a driver of obesity and metabolic syndrome
15:56 — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped
17:40— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain
21:45 — Is fructose a root cause of Alzheimer’s?
26:27 — New research suggests fructose induces a foraging response
28:20 — Fructose inhibits areas of the brain to encourage successful foraging
46:36 — We need more research on fructose
1:02:51 —Is fructose a factor in violence?
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Transcripts & Show notes: https://www.levelshealth.com/podcasts/214-is-fructose-a-driver-of-alzheimers-disease-dr-richard-johnson-dr-rob-lustig
Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author
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