A recent study out of the Baylor College of Medicine has shown that combining two OTC supplements can slow or reverse age-related cognitive decline.
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Links:
https://www.mdpi.com/2076-3921/12/5/1042
https://pubmed.ncbi.nlm.nih.gov/35268089/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002905/
https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.372
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As we grow older, some more gracefully than others, I hope we all aspire to live long healthy lives, as free as possible, from the natural decline of cognitive abilities that accompany the aging process. At the Baylor College of Medicine, researchers have been studying the biological underpinnings of age-associated cognitive decline, and developing nutritional strategies to promote healthy brain aging. The study that was published in the journal Antioxidants showed that supplementing with GlyNAC improved or reversed age-associated cognitive decline in old mice, and improved multiple associated defects in the aging brain. GlyNAC is a combination of glycine and N-acetylcysteine (more commonly known as NAC) precursors of the natural antioxidant glutathione. These findings are consistent with improvements observed after supplementing older adults with GlyNAC, as reported in their 2021 human pilot trial; intimating that the findings reported here, are likely to apply to humans also.
Dr. Rajagopal Sekhar, senior author of the study, and Professor of Medicine, endocrinology, diabetes and metabolism at the Baylor College of Medicine said “My lab has been studying natural aging in older humans, and aged mice, for over two decades. Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism, insulin resistance, inflammation and low levels of neurotrophic or neuron-supporting factors – and that supplementing GlyNAC reverses these defects and improves cognition.”
Human studies only permit measurements at the whole-body level, so in this study the researchers looked at mice to directly investigate defects in the aging brain. This study is important for a number of reasons: it assesses the reversibility of naturally occurring cognitive decline in aging – instead of cognitive decline resulting from introducing gene defects. Increased age is identified as the most important risk factor for Alzheimer’s disease; and these naturally occurring defects were studied directly in the brain. Professor Sekhar and his team worked with three separate groups of mice. Two groups were aged naturally – side-by-side – until they were 90 weeks old, which is similar to a 70-year-old person. The third group consisted of young mice.
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