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Paean Biotechnology is developing anti-inflammatory and anti-cancer drugs based on mitochondria separated from human umbilical cord-mesenchymal stem cell (UC-MSC).
Paean Biotechnology is developing anti-inflammatory and anti-cancer drugs based on mitochondria separated from human umbilical cord-mesenchymal stem cell (UC-MSC).
Mitochondria therapeutics is a therapeutic agent based on mitochondria separated from stem cells, and includes PN-101 for an inflammatory rare disease called multiple myositis and PN-102 for sepsis.
PN-201 of cell therapeutics is the cell therapeutics using the mitochondria with amplified the anticancer effect by delivering the mitochondria isolated from stem cells into NK cells. Protein therapeutics is a therapeutic agent that uses a technology that uses “modified mitochondria” made by combining PN-301 made by making anti-cancer protein to mitochondria and PN-302 made by marking single antibody chain.
PN-101 has been confirmed for efficacy in a disease animal model and has been tested for toxicity in a GLP institution, and is in the process of preparing an IND for phase 1 clinical trial. PN-102 has been confirmed to have a significant reduction in mortality in animals with sepsis, and the mechanism of regulating immunity due to the cytokine storm in hyperinflammatory conditions and immune paralysis that are immunological characteristics of sepsis.
PN-201 has been confirmed the cancer cell killing ability of mitochondrial-enhanced NK cells and the survival rate increase in animal models, and patents were registered for intracellular mitochondrial delivery and NK cell therapeutics including foreign mitochondria.
The platform technologies of PN-301 and PN-302 include a technique for producing ‘modified mitochondria” by connecting a protein that induces apoptosis of recombinant cancer and a single-chain variable fragment (scFv) antibody to the mitochondrial surface. We have confirmed that “modified mitochondria” targets cancer cells and suppresses tumor growth. Protein delivery technology using mitochondria is an innovative platform technology that can be compared to antibody-drug conjugates that can deliver various types of proteins into cells by targeting cells through scFv.
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