Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.
Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.
Show notes and transcript available:
https://www.foundmyfitness.com/episodes/morgan-levine
Pre-order Dr. Morgan Levine’s new book True Age:
https://www.amazon.com/True-Age-Cutting-Edge-Research-Clock/dp/0593329287
CHAPTERS:
00:01:19 – What is aging?
00:03:20 – Why biological aging matters to scientists
00:04:45 – Hallmarks of aging
00:05:24 – What are the drivers of aging?
00:06:58 – What CpG methylation says about aging
00:08:59 – The advantage of epigenetic clocks in research
00:10:12 – New generation epigenetic clocks: GrimAge and PhenoAge
00:11:51 – Clinical biomarkers vs. epigenetic clocks
00:12:50 – Differences in aging between organ systems
00:16:47 – Do some people age faster than others?
00:19:05 – Epigenetic age acceleration
00:20:39 – Is age acceleration a genetic risk inherited from your parents?
00:22:27 – The effects of menopause on aging
00:23:16 – Does the pace of epigenetic aging change throughout life?
00:24:39 – How does obesity and human disease affect epigenetic aging?
00:26:12 – Why genes from development may be key to understanding aging
00:27:13 – Determining epigenetic age in non-human mammals (all of them)
00:27:50 – Is aging an accident of evolution or by design? (See also 00:48:20)
00:30:17 – What happens to the epigenetic age of immortal cells if you grow them forever?
00:31:40 – Effects of cancer treatment on epigenetic age
00:35:43 – Severe COVID-19 and accelerated epigenetic
00:36:40 – Are epigenetic changes in aging a cause or consequence?
00:39:23 – Are the CpG sites used by epigenetic clocks functionally meaningful?
00:42:15 – Reversing epigenetic age with interrupted reprogramming techniques
00:49:27 – Therapeutic plasma exchange in aging and pro-geronic blood factors
00:53:23 – The effects of neutral plasma exchange on the brain
00:56:01 – Lifestyle factors that accelerate epigenetic age
00:57:56 – The aging acceleration effect of smoking
00:59:37 – Omega-3 hypermethylation of inflammatory pathways
01:03:23 – Reliability of consumer epigenetic clock tests
01:06:12 – Construct validity of epigenetic clocks
01:12:06 – Thoughts on most exciting research in aging field
01:13:44 – Dr. Morgan Levine’s lifestyle habits
01:15:00 – Intermittent fasting effects on epigenetic age
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