#psoriasis pathogenesis is a spectrum of #autoimmune to #autoinflammatory processes. In #netosis, FROM ONE SIDE: #proteases and enzymes that are components of the nets cause INJURY to surrounding cells & augmenting #inflammation. FROM THE OTHER SIDE: #nets release more than 70 known #autoantigens that can cause #autoimmunity.
REFERRENCES:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590568/#:~:text=NETosis%20is%20a%20program%20for,physiological%20stimuli%20can%20cause%20NETosis.
https://pubmed.ncbi.nlm.nih.gov/36000086/
https://pubmed.ncbi.nlm.nih.gov/35409152/#:~:text=Proteases%20and%20enzymes%20released%20from,over%2070%20well%2Dknown%20autoantigens.
https://www.frontiersin.org/articles/10.3389/fimmu.2022.911347/full#:~:text=Emerging%20evidence%20has%20indicated%20that,%2C%20in%20PsO%20(20).
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