#NAD #mitochondria #davidsinclair #SLC25A51
NAD levels decline with age, and administration of NAD precursors like NMN is currently being tested in the clinic as a measure to prevent age-associated diseases. So understanding the flux of NAD in the cell is of great importance.
So far it has not been clarified how mitochondria within our cells gain access to NAD. This week a paper was released which identified a transporter that moves NAD into the mitochondria. In this video we look at this paper and one previous one in which it was shown how NAD is moved to the mitochondria and which transporter is responsible.
References:
Dr. Sinclair article
https://www.researchgate.net/publication/330203173_The_elusive_NMN_transporter_is_found
Dr. Imai slc12a8 paper
https://www.nature.com/articles/s42255-018-0009-4
SLC25A51 regulates the transport of the coenzyme NAD into the mitochondria
https://phys.org/news/2020-12-slc25a51-coenzyme-nad-mitochondria.html
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
https://www.nature.com/articles/s41467-020-19871-x
SLC25A51 is a mammalian mitochondrial NAD+ transporter
https://www.nature.com/articles/s41586-020-2741-7
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