Pathology Presents: Peter Rabinovitch, MD, PhD | “The Central Role of Mitochondrial Energetics and Redox Status in Cardiac Aging: Or, So long, and thanks for all the fish…”
UW Pathology Presents
“The Central Role of Mitochondrial Energetics and Redox Status in Cardiac Aging
Or
So long, and thanks for all the fish…”
Peter Rabinovitch, MD, PhD
Professor and Vice Chair of Research
Department of Laboratory Medicine & Pathology
University of Washington
Why Attend this Seminar?
Aging is the primary risk factor for essentially all chronic diseases, however, it is a relatively recent understanding that the aging process is not immutable. For organs that are highly energy-dependent, including the heart, our work and others has shown that mitochondrial dysfunction during aging is a primary factor in declining organ function. Recent work with mitochondrial targeted interventions, including mitochondrial targeted catalase (mCAT), the peptide drug elamipretide (SS-31) and nicotinamide mononucleotide (NMN), has demonstrated the potential of such strategies to attenuate, and even reverse aging changes and we are beginning to better understand the molecular mechanisms by which this takes place.
Chapters:
0:00 – Introduction by Dr. Alexander Mendenhall
0:45 – Dr. Rabinovitch’s Presentation
46:10 – Q&A
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