Presented By:
Prof. Cathy Thornton, PhD
Salvador Vento Asturias, PhD
Speaker Biography:
Prof Thornton holds a Professorship of Human Immunology at Swansea University where she is also Head of the Medical School. Her research has been centered on exploring basic mechanisms underlying differences in (i) immune function at birth, and (ii) pregnancy and adverse pregnancy outcomes. Among her success she is recognized for her expertise in the early life origins of immune mediated diseases. Currently her research focus is on maternal air pollution exposures, fetal programming, and child health. Her efforts have been awarded funding from UKRI, Diabetes UK, and the Welsh Government.
Salva is a Junior product manager (Global) for cell separation reagents at Miltenyi Biotec. He earned his PhD in Immunology. His dissertation was on “CD8 T cell responses during primary and secondary influenza infection – Role of MHC-I expression on non-immune cells”. He is passionate about moving research forward.
Webinar:
Revealing the role of Mononuclear phagocytes in human pregnancy via automated high purity isolation
Webinar Abstract:
It is known that the immune response in pregnant women undergoes recognized changes that ensure the mother does not reject the fetus. Dysregulation of this dynamic immune adaptation underpins numerous adverse pregnancy outcomes such as miscarriage, preeclampsia, and preterm birth. These normal changes in the immune response also make pregnant women more susceptible to severe infections of influenza, measles, and hepatitis E and affect clinical symptoms of autoimmune diseases. Despite the knowledge of these immune response changes, little is known about how immune cells undergo functional changes during pregnancy.
Here, we show how a high purity automated isolation from blood and tissue mononuclear phagocytes allow for an accurate investigation to further understand how these changes occur at the cellular level. Flow cytometry, bioenergetics analysis and transcriptomics were used to monitor the immunometabolic profile of mononuclear phagocytes during pregnancy. We can apply this knowledge to other immune cell populations and also to bridge the many gaps in the basic, translational, and clinical immunology of pregnancy.
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