1,What is Adipotide?
Adipotide, also known as FTPP (fat-targeting proapoptotic peptide), is an investigational peptide intended for use as a possible treatment for obesity. In order to reduce fat mass and address obesity-related problems, it attempts to trigger apoptosis of fat cells, specifically in white adipose tissue.
2,How Adipotide Works?
① Receptor binding: Adipotide’s unique structure contains a specific amino acid sequence designed to bind to receptors. Thanks to these sequences, the peptide can attach to receptors on the outside of arteries that support white fat tissue. It primarily targets inhibin and ANXA2 (Annexin A2).
② Receptor interaction: Adipotide interacts with inhibin and ANXA2 receptors, thereby leading to the pathogenesis cellular process chain. In white adipose tissue, inhibin and ANXA2 are involved in cellular function and fatty acid transport.
③ Mitochondrial damage: The structure of adipose peptide contains sequences that can break down mitochondria in fat cells. The energy-producing organelles in cells are called mitochondria. Interference with adipopeptides can lead to mitochondrial dysfunction and damage.
④Apoptosis: Apoptosis or programmed cell death occurs in adipocytes due to the damage of mitochondria by adipose peptides and the resulting cellular stress. Through this process, cells naturally remove damaged or unwanted cells from the body.
⑤Adipocyte elimination: Over time, as more adipocytes are exposed to adipose peptides and undergo apoptosis, the amount of white adipose tissue decreases. This may reduce fat accumulation in the body’s intended target locations.
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