Tuesday, May 28, 2024
Mitochondrial Health

#116 – AMA with Dom D’Agostino, Ph.D., Half I of II: Ketogenic weight loss plan, exogenous ketones, and train

Again by extremely popular demand for a particular AMA episode, ketosis skilled Dom D’Agostino joins Bob Kaplan, Peter’s Head of Analysis, to deal with many lingering questions in regards to the ketogenic weight loss plan, exogenous ketones, and train for general well being. Dom additionally shares worthwhile insights from his private expertise with coaching, dietary supplements, intermittent fasting, and different dietary methods to optimize his personal well being and efficiency. For those who’re not a subscriber and listening on a podcast participant, you’ll solely be capable to hear a preview of the AMA.  For those who’re a subscriber, now you can take heed to this full episode in your private RSS feed or on the web site show notes web page.


We talk about:

  • Dom’s current and ongoing tasks [3:00];
  • Advantages of a ketogenic weight loss plan for an in any other case wholesome individual [7:00];
  • Ebook suggestions for getting educated on the ketogenic weight loss plan [11:30];
  • Finest units for measuring ketones [13:45];
  • Genetic elements that affect how somebody responds to the ketogenic weight loss plan [24:45];
  • Ketogenic weight loss plan for these with the APOE e4 allele [28:15];
  • Affect of long-term ketogenic diets on thyroid perform [34:25];
  • Low-carb and ketogenic diets for urge for food management and weight administration [39:00];
  • Ketogenic weight loss plan and the microbiome [43:00];
  • Evaluating monounsaturated fats versus saturated fats on the ketogenic weight loss plan [45:55];
  • Implications of long-term genetic and epigenetic variations to a ketogenic weight loss plan [47:45];
  • Why some folks see an increase in LDL-C and LDL-P when on a ketogenic weight loss plan and what they will do about it [50:15];
  • Ought to somebody with familial hypercholesterolemia contemplate the ketogenic weight loss plan? [55:00];
  • Exogenous ketones—advantages, therapeutic makes use of, and ketone dietary supplements that Dom has examined [56:45];
  • Ketogenic protocols for administration of traumatic mind accidents [1:06:00];
  • Evaluating the advantages and therapeutic makes use of of assorted medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45];
  • Nootropics, caffeine, and different stimulants [1:16:15];
  • Supplemental use of testosterone, DHEA, and creatine for muscle development and efficiency [1:23:45];
  • Affect of fasted-state coaching on power and efficiency [1:30:15];
  • Stacking exogenous ketones with MCTs for optimum effectiveness [1:33:30];
  • BCAA dietary supplements throughout a quick for muscle preservation [1:35:45];
  • What app is Dom utilizing for monitoring his macros? [1:42:00];
  • Getting sufficient micronutrients whereas on a ketogenic weight loss plan [1:47:15];
  • Very best macros for staying in ketosis whereas getting sufficient protein for power coaching [1:48:15];
  • Professionals, cons, and ultimate macros of 1 meal a day [1:51:15];
  • Dom’s tackle “carb backloading” [1:54:45];
  • Dom’s tackle “carb up” days for ketogenic dieters [2:01:00];
  • Dom’s ideas on the carnivore weight loss plan and the paleolithic ketogenic weight loss plan [2:05:30];
  • Benefit of the ketogenic weight loss plan for excessive endurance athletes [2:10:30];
  • Affect on power, energy, and efficiency of the difference interval to the ketogenic weight loss plan [2:14:00];
  • Fasted-state elevation in development hormone and its impression on coaching [2:17:45];
  • Is it doable to construct muscle on a ketogenic weight loss plan? [2:23:30];
  • Why Dom took a yr off from weight coaching [2:28:00];
  • What does Dom do for cardio train? [2:30:45];
  • Protocols for exhausting coaching restoration [2:33:15];
  • Dom’s private method to fasting, time-restricted consuming, and sleep [2:35:45];
  • Folks, books, and different assets that formed Dom’s coaching and diet [2:38:45]; and
  • Extra.


Dom’s current and ongoing tasks [3:00]

The principle goal in final 2 years: Attempting to maneuver the laboratory science into human functions


NASA Extreme Environment Mission Operations analysis

  • Dom was a crew member for NEEMO 22
  • His spouse was a crew member for NEEMO 23
  • This undertaking is evaluating the consequences of hyperbaric environments, excessive environments on human physiology
  • They now have an IRB protocol for cognitive perform, physique composition, intestine microbiome, sleep, coronary heart charge variability, and stress

Results of ketones on most cancers cachexia

  • They’re trying on the results of ketones on mitigating most cancers cachexia and losing related to metastatic most cancers 
  • Dom simply published a manuscript 

Metabolic therapies for varied genetic ailments 


Advantages of a ketogenic weight loss plan for an in any other case wholesome individual [7:00]

Intermittent ketosis

  • The principle profit is that it promotes metabolic flexibility
  • Most individuals are tailored to frequent carbohydrate feedings
  • And they aren’t tailored to utilizing fats as a serious vitality supply throughout instances of restricted carbohydrate availability or calorie availability in periods of fasting
  • Ketosis (and/or fasting) prompts a genetic program that means that you can burn fats and make ketones extra effectively
  • It might take a while, however you’ve an innate means to be metabolically versatile, so the extra you do intermittent ketosis (or fasting), the extra advantages you derive from it over time

Glucose-ketone index and insulin suppression

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer

  • The factor to focus on can be the glucose-ketone index

    • For instance, you can prohibit energy by 50% on a ketogenic weight loss plan and try this for six days a month and obtain, a glucose-ketone index between 1 and a couple of
  • Insulin suppression additionally happens
  • Doing a restricted ketogenic weight loss plan mixed that with time-restricted feeding, you’re hitting all the foremost drivers of the advantages that you simply’d get from fasting corresponding to:

    • suppressed mTOR
    • suppressed insulin
    • It’s additionally most likely stimulating autophagy

*Suggestion from Dom: As soon as a month, attempt to do 5-7 days of a ketogenic weight loss plan proscribing energy by 50%


Ebook suggestions for getting educated on the ketogenic weight loss plan [11:30]

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Dom D’Agostino, Ph.D.

Dom is an Affiliate Professor on the College of South Florida the place he teaches on the Morsani Faculty of Medication and the Division of Molecular Pharmacology and Physiology. He focuses on neuropharmacology, medical biochemistry, physiology, neuroscience, neuropharmacology. Dom holds a PhD in neuroscience and physiology. [See full bio at KetoNutrition.org]

Twitter: @DominicDAgosti2

Instagram: @dominic.dagostino.kt

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