My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research.
Dr. Kennedy’s lab is working on different small molecules and natural products that could boost longevity. In today’s discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.
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DR. BRIAN KENNEDY LINKS:
Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/
Twitter: https://twitter.com/BKennedy_aging
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TIMESTAMPS:
00:00 Live Longer World
00:35 Brian Kennedy Intro
1:24 Differences in lifespan vs healthspan in his grandmothers
3:37 Network concept of the hallmarks of Aging
7:17 Open questions on hallmarks of aging; combining interventions
13:08 Comparing biomarkers of aging
16:11 Alpha-Ketoglutarate (AKG) and Longevity
23:55 Aging across different ethnicities
26:00 Socioeconomic & housing differences contributing to aging
29:40 Spermidine & Autophagy
31:59 Different longevity supplements may cancel each other out
35:18 AKG in extended release form
36:24 AKG & Red Blood Cells + Glutathione production
38:43 Mechanisms by which AKG works; AKG & Microbiome
40:07 Urolithin A, Mitochondria & Longevity
41:55 Longevity of Bats!
47:57 Yeast as model organisms for aging research
50:24 Advocating for Basic Science Research (Feynman: The Pleasure of Finding Things Out)
57:34 Support, share, and follow Live Longer World
DR. BRIAN KENNEDY RESEARCH DISCUSSED:
2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/
2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/
2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/
2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/
2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081
Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share!
Stay in good health – Aastha.
#briankennedy #akg #spermidine #urolithin #batlongevity #longevity #antiaging #biomarkers
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