In this video i spoke with Dr Brandon Berry, a current Post-Doctoral fellow at the University of Washington, where he is developing and using tools to understand the function of mitochondria and their link with diseases and aging. Here, we discuss these interests further and the results from his latest publication one tool, termed ‘mitochondria-ON’, extended worm lifespan. ‘Mitochondria-ON’ rejuvenates the mitochondrial membrane potential when exposed to light and all-trans-retinal using optogenetics.
Find Brandon on Twitter – https://twitter.com/mitobrandon
Research papers – Berry, B.J., Vodičková, A., Müller-Eigner, A. et al. Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00340-7
Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance https://www.embopress.org/doi/full/10.15252/embr.201949113
Berry, B.J., Kaeberlein, M. An energetics perspective on geroscience: mitochondrial protonmotive force and aging. GeroScience 43, 1591–1604 (2021). https://doi.org/10.1007/s11357-021-00365-7
Find me on Twitter – https://twitter.com/EleanorSheekey
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TIMESTAMPS
Intro – 00:00
Mitochondria and proton motive force – 01:10
Optogenetic tools manipulate membrane potential – 08:45
Lifespan studies – 17:55
Consequences of recharging – 30:00
Cellular senescence – 36:30
Academia & advice – 38:30
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; “https://www.freepik.com/free-photos-vectors/background”Background vector created by freepik – www.freepik.com
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